FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084955929> ?p ?o ?g. }

• W2084955929 endingPage "53" @default.
• W2084955929 startingPage "36" @default.
• W2084955929 abstract "Post-translational modification of histones plays essential roles in the transcriptional regulation of genes in eukaryotes. Methylation on basic residues of histones is regulated by histone methyltransferases and histone demethylases, and misregulation of these enzymes has been linked to a range of diseases such as cancer. Histone lysine demethylase 2 (KDM2) family proteins have been shown to either promote or suppress tumorigenesis in different human malignancies. However, the roles and regulation of KDM2 in development are poorly understood, and the exact roles of KDM2 in regulating demethylation remain controversial. Since KDM2 proteins are highly conserved in multicellular animals, we analyzed the KDM2 ortholog in Drosophila. We have observed that dKDM2 is a nuclear protein and its level fluctuates during fly development. We generated three deficiency lines that disrupt the dKdm2 locus, and together with 10 transposon insertion lines within the dKdm2 locus, we characterized the developmental defects of these alleles. The alleles of dKdm2 define three phenotypic classes, and the intragenic complementation observed among these alleles and our subsequent analyses suggest that dKDM2 is not required for viability. In addition, loss of dKDM2 appears to have rather weak effects on histone H3 lysine 36 and 4 methylation (H3K36me and H3K4me) in the third instar wandering larvae, and we observed no effect on methylation of H3K9me2, H3K27me2 and H3K27me3 in dKdm2 mutants. Taken together, these genetic, molecular and biochemical analyses suggest that dKDM2 is not required for viability of flies, indicating that dKdm2 is likely redundant with other histone lysine demethylases in regulating normal development in Drosophila." @default.
• W2084955929 created "2016-06-24" @default.
• W2084955929 creator A5035659770 @default.
• W2084955929 creator A5039326076 @default.
• W2084955929 creator A5040552741 @default.
• W2084955929 creator A5054147388 @default.
• W2084955929 creator A5067454311 @default.
• W2084955929 creator A5076770541 @default.
• W2084955929 creator A5087569460 @default.
• W2084955929 creator A5090399672 @default.
• W2084955929 date "2014-08-01" @default.
• W2084955929 modified "2023-10-16" @default.
• W2084955929 title "A developmental genetic analysis of the lysine demethylase KDM2 mutations in Drosophila melanogaster" @default.
• W2084955929 cites W1580062104 @default.
• W2084955929 cites W1969451832 @default.
• W2084955929 cites W1969585647 @default.
• W2084955929 cites W1973770081 @default.
• W2084955929 cites W1975472671 @default.
• W2084955929 cites W1975746577 @default.
• W2084955929 cites W1980333298 @default.
• W2084955929 cites W1981259598 @default.
• W2084955929 cites W1984853047 @default.
• W2084955929 cites W1986642666 @default.
• W2084955929 cites W1990711772 @default.
• W2084955929 cites W2009858080 @default.
• W2084955929 cites W2010970917 @default.
• W2084955929 cites W2011392391 @default.
• W2084955929 cites W2011482055 @default.
• W2084955929 cites W2012980659 @default.
• W2084955929 cites W2013317474 @default.
• W2084955929 cites W2014640188 @default.
• W2084955929 cites W2015735594 @default.
• W2084955929 cites W2017152304 @default.
• W2084955929 cites W2018732798 @default.
• W2084955929 cites W2028980592 @default.
• W2084955929 cites W2034340491 @default.
• W2084955929 cites W2035271418 @default.
• W2084955929 cites W2037149683 @default.
• W2084955929 cites W2037366394 @default.
• W2084955929 cites W2037967594 @default.
• W2084955929 cites W2038838628 @default.
• W2084955929 cites W2043823295 @default.
• W2084955929 cites W2048855155 @default.
• W2084955929 cites W2053827552 @default.
• W2084955929 cites W2054643318 @default.
• W2084955929 cites W2057808113 @default.
• W2084955929 cites W2060712252 @default.
• W2084955929 cites W2066608154 @default.
• W2084955929 cites W2068946710 @default.
• W2084955929 cites W2080326437 @default.
• W2084955929 cites W2080539420 @default.
• W2084955929 cites W2082509129 @default.
• W2084955929 cites W2092138220 @default.
• W2084955929 cites W2092575519 @default.
• W2084955929 cites W2092716906 @default.
• W2084955929 cites W2095111355 @default.
• W2084955929 cites W2100270425 @default.
• W2084955929 cites W2111098183 @default.
• W2084955929 cites W2115266888 @default.
• W2084955929 cites W2123552387 @default.
• W2084955929 cites W2127604631 @default.
• W2084955929 cites W2132133351 @default.
• W2084955929 cites W2132632499 @default.
• W2084955929 cites W2133452708 @default.
• W2084955929 cites W2147477246 @default.
• W2084955929 cites W2147524392 @default.
• W2084955929 cites W2153771353 @default.
• W2084955929 cites W2157460414 @default.
• W2084955929 cites W2158714788 @default.
• W2084955929 cites W2161597083 @default.
• W2084955929 cites W2167364244 @default.
• W2084955929 cites W2169702314 @default.
• W2084955929 cites W2172060732 @default.
• W2084955929 cites W2172085202 @default.
• W2084955929 cites W2193330140 @default.
• W2084955929 doi "https://doi.org/10.1016/j.mod.2014.06.003" @default.
• W2084955929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4177295" @default.
• W2084955929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25016215" @default.
• W2084955929 hasPublicationYear "2014" @default.
• W2084955929 type Work @default.
• W2084955929 sameAs 2084955929 @default.
• W2084955929 citedByCount "18" @default.
• W2084955929 countsByYear W20849559292015 @default.
• W2084955929 countsByYear W20849559292016 @default.
• W2084955929 countsByYear W20849559292017 @default.
• W2084955929 countsByYear W20849559292018 @default.
• W2084955929 countsByYear W20849559292019 @default.
• W2084955929 countsByYear W20849559292020 @default.
• W2084955929 countsByYear W20849559292021 @default.
• W2084955929 countsByYear W20849559292022 @default.
• W2084955929 crossrefType "journal-article" @default.
• W2084955929 hasAuthorship W2084955929A5035659770 @default.
• W2084955929 hasAuthorship W2084955929A5039326076 @default.
• W2084955929 hasAuthorship W2084955929A5040552741 @default.
• W2084955929 hasAuthorship W2084955929A5054147388 @default.
• W2084955929 hasAuthorship W2084955929A5067454311 @default.
• W2084955929 hasAuthorship W2084955929A5076770541 @default.
• W2084955929 hasAuthorship W2084955929A5087569460 @default.

• next