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- W2084961129 abstract "Development of a topical pharmaceutical is facilitated by generation of a different type of preformulation profile than needed prior to tablet or parenteral product development. Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) drug marketed in Japan for the topical relief of primary thermal burns and sunburns. A complete preformation characterization was completed for this compound and is reported here to serve as a template for development of future topical drug products. The physical properties compiled include melting properties, specific gravity, viscosity, hygroscopicity, moisture content, acid-base properties, surface tension, solubility and partitioning. Chemical stability results are given for the bulk drug, the drug in solution, and the drug after formulation in both a cream and an ointment. These studies indicate that ibuprofen piconol is a chemically stable, slightly hygroscopic liquid that strongly partitions into the oil phase and shows no indication of surface activity. This drug has very limited solubility in water (16.5 ppm), modest solubility in glycerol (16.4 mg/ml), and is miscible with less polar organics except for silicone fluids." @default.
- W2084961129 created "2016-06-24" @default.
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- W2084961129 date "1993-01-01" @default.
- W2084961129 modified "2023-09-25" @default.
- W2084961129 title "Preformulation characterization of topical Ibuprofen Piconol" @default.
- W2084961129 cites W2094049167 @default.
- W2084961129 doi "https://doi.org/10.3109/03639049309073896" @default.
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