FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084967013> ?p ?o ?g. }

• W2084967013 endingPage "2351" @default.
• W2084967013 startingPage "2335" @default.
• W2084967013 abstract "We describe ATP-dependent inhibition of the 75–105-pS (in 250 mM Cl−) anion channel (SCl) from the sarcoplasmic reticulum (SR) of rabbit skeletal muscle. In addition to activation by Ca2+ and voltage, inhibition by ATP provides a further mechanism for regulating SCl channel activity in vivo. Inhibition by the nonhydrolyzable ATP analog 5′-adenylylimidodiphosphate (AMP-PNP) ruled out a phosphorylation mechanism. Cytoplasmic ATP (∼1 mM) inhibited only when Cl− flowed from cytoplasm to lumen, regardless of membrane voltage. Flux in the opposite direction was not inhibited by 9 mM ATP. Thus ATP causes true, current rectification in SCl channels. Inhibition by cytoplasmic ATP was also voltage dependent, having a KI of 0.4–1 mM at −40 mV (Hill coefficient ∼2), which increased at more negative potentials. Luminal ATP inhibited with a KI of ∼2 mM at +40 mV, and showed no block at negative voltages. Hidden Markov model analysis revealed that ATP inhibition 1) reduced mean open times without altering the maximum channel amplitude, 2) was mediated by a novel, single, voltage-independent closed state (∼1 ms), and 3) was much less potent on lower conductance substates than the higher conductance states. Therefore, the SCl channel is unlikely to pass Cl− from cytoplasm to SR lumen in vivo, and balance electrogenic Ca2+ uptake as previously suggested. Possible roles for the SCl channel in the transport of other anions are discussed." @default.
• W2084967013 created "2016-06-24" @default.
• W2084967013 creator A5033670721 @default.
• W2084967013 creator A5085253794 @default.
• W2084967013 date "1998-05-01" @default.
• W2084967013 modified "2023-10-18" @default.
• W2084967013 title "ATP Inhibition and Rectification of a Ca2+-Activated Anion Channel in Sarcoplasmic Reticulum of Skeletal Muscle" @default.
• W2084967013 cites W134090569 @default.
• W2084967013 cites W1501535983 @default.
• W2084967013 cites W1579090468 @default.
• W2084967013 cites W1596332074 @default.
• W2084967013 cites W1963674209 @default.
• W2084967013 cites W1964709412 @default.
• W2084967013 cites W1983062801 @default.
• W2084967013 cites W1983240254 @default.
• W2084967013 cites W1995179761 @default.
• W2084967013 cites W2002117344 @default.
• W2084967013 cites W2007552499 @default.
• W2084967013 cites W2010455912 @default.
• W2084967013 cites W2011276646 @default.
• W2084967013 cites W2014626166 @default.
• W2084967013 cites W2016203915 @default.
• W2084967013 cites W2018941689 @default.
• W2084967013 cites W2021393935 @default.
• W2084967013 cites W2028357288 @default.
• W2084967013 cites W2030937954 @default.
• W2084967013 cites W2036701273 @default.
• W2084967013 cites W2037138364 @default.
• W2084967013 cites W2039425559 @default.
• W2084967013 cites W2055492577 @default.
• W2084967013 cites W2056284444 @default.
• W2084967013 cites W2056556864 @default.
• W2084967013 cites W2056930596 @default.
• W2084967013 cites W2059647854 @default.
• W2084967013 cites W2059845021 @default.
• W2084967013 cites W2060055554 @default.
• W2084967013 cites W2060755243 @default.
• W2084967013 cites W2061592889 @default.
• W2084967013 cites W2067172338 @default.
• W2084967013 cites W2078644872 @default.
• W2084967013 cites W2081083547 @default.
• W2084967013 cites W2081441438 @default.
• W2084967013 cites W2081900131 @default.
• W2084967013 cites W2084386763 @default.
• W2084967013 cites W2085771717 @default.
• W2084967013 cites W2092020962 @default.
• W2084967013 cites W2105393278 @default.
• W2084967013 cites W2117208932 @default.
• W2084967013 cites W2121015363 @default.
• W2084967013 cites W2125199990 @default.
• W2084967013 cites W2133464980 @default.
• W2084967013 cites W2136225082 @default.
• W2084967013 cites W2169119107 @default.
• W2084967013 cites W2410403490 @default.
• W2084967013 cites W2413239797 @default.
• W2084967013 cites W51182960 @default.
• W2084967013 doi "https://doi.org/10.1016/s0006-3495(98)77943-3" @default.
• W2084967013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1299577" @default.
• W2084967013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9591661" @default.
• W2084967013 hasPublicationYear "1998" @default.
• W2084967013 type Work @default.
• W2084967013 sameAs 2084967013 @default.
• W2084967013 citedByCount "31" @default.
• W2084967013 countsByYear W20849670132012 @default.
• W2084967013 countsByYear W20849670132013 @default.
• W2084967013 countsByYear W20849670132014 @default.
• W2084967013 countsByYear W20849670132017 @default.
• W2084967013 countsByYear W20849670132018 @default.
• W2084967013 countsByYear W20849670132023 @default.
• W2084967013 crossrefType "journal-article" @default.
• W2084967013 hasAuthorship W2084967013A5033670721 @default.
• W2084967013 hasAuthorship W2084967013A5085253794 @default.
• W2084967013 hasBestOaLocation W20849670131 @default.
• W2084967013 hasConcept C121332964 @default.
• W2084967013 hasConcept C121932024 @default.
• W2084967013 hasConcept C12554922 @default.
• W2084967013 hasConcept C134018914 @default.
• W2084967013 hasConcept C158617107 @default.
• W2084967013 hasConcept C181911157 @default.
• W2084967013 hasConcept C185592680 @default.
• W2084967013 hasConcept C190062978 @default.
• W2084967013 hasConcept C26873012 @default.
• W2084967013 hasConcept C2779959927 @default.
• W2084967013 hasConcept C55493867 @default.
• W2084967013 hasConcept C86803240 @default.
• W2084967013 hasConceptScore W2084967013C121332964 @default.
• W2084967013 hasConceptScore W2084967013C121932024 @default.
• W2084967013 hasConceptScore W2084967013C12554922 @default.
• W2084967013 hasConceptScore W2084967013C134018914 @default.
• W2084967013 hasConceptScore W2084967013C158617107 @default.
• W2084967013 hasConceptScore W2084967013C181911157 @default.
• W2084967013 hasConceptScore W2084967013C185592680 @default.
• W2084967013 hasConceptScore W2084967013C190062978 @default.
• W2084967013 hasConceptScore W2084967013C26873012 @default.
• W2084967013 hasConceptScore W2084967013C2779959927 @default.
• W2084967013 hasConceptScore W2084967013C55493867 @default.
• W2084967013 hasConceptScore W2084967013C86803240 @default.
• W2084967013 hasIssue "5" @default.

• next