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• W2084973089 abstract "The colonial ascidian Botryllus schlosseri manifests a unique allorecognition system that is controlled by a single histocompatibility haplotype, the Fu/HC locus. When two allogeneic incompatible colonies come into direct contact, they develop inflammatory-like rejection lesions, called points of rejection (POR). While screening for differentially expressed genes during POR formation, we developed and analyzed a cDNA library of expressed sequence tags (ESTs) with 1693 unique ESTs that were clustered and assembled into 217 contigs and 1476 singlets. About 51% of these ESTs showed high similarity (E-value 0.005) to known database sequences, of which 123 matches were identified as immune-relevant genes encoding for stress proteins, pattern recognition receptors and complement proteins, proteases and protease inhibitors, cell adhesion and coagulation proteins, cytokine-related proteins, programmed cell death and proteasome-associated proteins. This first EST wide-screening analysis of the Botryllus allorecognition effector arm reveals a complex innate immune system, hallmarked by a whole genome response to allorecognition challenge." @default.
• W2084973089 created "2016-06-24" @default.
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• W2084973089 date "2007-01-01" @default.
• W2084973089 modified "2023-09-30" @default.
• W2084973089 title "Identification of immune-relevant genes in histoincompatible rejecting colonies of the tunicate Botryllus schlosseri" @default.
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• W2084973089 doi "https://doi.org/10.1016/j.dci.2006.12.009" @default.
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