Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084978346> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2084978346 abstract "1. The effects of AFD-21, a newly synthesized antiarrhythmic compound, and AFD-19, its active metabolite, on transmembrane action potentials were examined in right ventricular papillary muscles and single ventricular myocytes isolated from guinea-pig hearts. 2. In papillary muscles, AFD-21 10(-5) M caused a slight prolongation of action potential duration (APD), while AFD-19 above 10(-6) M shortened APD in a dose-dependent manner. 3. Both AFD-21 and AFD-19 above 10(-6) M caused a significant and dose-dependent decrease in the maximum upstroke velocity (Vmax) of the action potential without affecting the resting membrane potential. 4. In the presence of AFD-21 or AFD-19, trains of stimuli at rates greater than or equal to 0.2 Hz led to an exponential decline in Vmax. This use-dependent block was enhanced at higher stimulation frequencies. A time constant for the recovery of Vmax from the use-dependent block was 2.9 s for AFD-21 and 3.6s for AFD-19. 5. The curves relating membrane potential and Vmax were shifted by AFD-21 (10(-5) M), or AFD-19 (10(-5) M) to the direction of more negative potentials by 5.3 mV and 5.1 mV respectively. 6. In single ventricular myocytes treated with AFD-21 (10(-5) M) or AFD-19 (10(-5) M), Vmax of test action potentials preceded by conditioning clamp pulses to 0 mV was decreased progressively as the clamp pulse duration was prolonged. 7. These findings suggest that both AFD-21 and AFD-19 have use- and voltage-dependent inhibitory action on the sodium channel by binding to the channel during its inactivated state, and that the unbinding rate is comparable to that of Class I antiarrhythmic drugs with intermediate kinetics." @default.
- W2084978346 created "2016-06-24" @default.
- W2084978346 creator A5002110232 @default.
- W2084978346 creator A5004782576 @default.
- W2084978346 creator A5024500340 @default.
- W2084978346 creator A5049043438 @default.
- W2084978346 creator A5079500797 @default.
- W2084978346 date "1990-12-01" @default.
- W2084978346 modified "2023-09-25" @default.
- W2084978346 title "Electrophysiological effects of AFD-21 and AFD-19, new antiarrythmic compounds on papillary muscles and single ventricular myocytes isolated from guinea-pig hearts" @default.
- W2084978346 cites W1956357205 @default.
- W2084978346 cites W1972081273 @default.
- W2084978346 cites W1997472615 @default.
- W2084978346 cites W2002594172 @default.
- W2084978346 cites W2003931877 @default.
- W2084978346 cites W2005208972 @default.
- W2084978346 cites W2025148785 @default.
- W2084978346 cites W2028167410 @default.
- W2084978346 cites W2032655162 @default.
- W2084978346 cites W2057475060 @default.
- W2084978346 cites W2059796887 @default.
- W2084978346 cites W2060366195 @default.
- W2084978346 cites W2069884282 @default.
- W2084978346 cites W2131952571 @default.
- W2084978346 cites W2155932859 @default.
- W2084978346 cites W2168564324 @default.
- W2084978346 doi "https://doi.org/10.1111/j.1476-5381.1990.tb14161.x" @default.
- W2084978346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1917845" @default.
- W2084978346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2085705" @default.
- W2084978346 hasPublicationYear "1990" @default.
- W2084978346 type Work @default.
- W2084978346 sameAs 2084978346 @default.
- W2084978346 citedByCount "0" @default.
- W2084978346 crossrefType "journal-article" @default.
- W2084978346 hasAuthorship W2084978346A5002110232 @default.
- W2084978346 hasAuthorship W2084978346A5004782576 @default.
- W2084978346 hasAuthorship W2084978346A5024500340 @default.
- W2084978346 hasAuthorship W2084978346A5049043438 @default.
- W2084978346 hasAuthorship W2084978346A5079500797 @default.
- W2084978346 hasBestOaLocation W20849783462 @default.
- W2084978346 hasConcept C105702510 @default.
- W2084978346 hasConcept C12554922 @default.
- W2084978346 hasConcept C126322002 @default.
- W2084978346 hasConcept C134018914 @default.
- W2084978346 hasConcept C158494493 @default.
- W2084978346 hasConcept C181911157 @default.
- W2084978346 hasConcept C185263204 @default.
- W2084978346 hasConcept C185592680 @default.
- W2084978346 hasConcept C24998067 @default.
- W2084978346 hasConcept C2778815084 @default.
- W2084978346 hasConcept C55493867 @default.
- W2084978346 hasConcept C71924100 @default.
- W2084978346 hasConcept C86803240 @default.
- W2084978346 hasConceptScore W2084978346C105702510 @default.
- W2084978346 hasConceptScore W2084978346C12554922 @default.
- W2084978346 hasConceptScore W2084978346C126322002 @default.
- W2084978346 hasConceptScore W2084978346C134018914 @default.
- W2084978346 hasConceptScore W2084978346C158494493 @default.
- W2084978346 hasConceptScore W2084978346C181911157 @default.
- W2084978346 hasConceptScore W2084978346C185263204 @default.
- W2084978346 hasConceptScore W2084978346C185592680 @default.
- W2084978346 hasConceptScore W2084978346C24998067 @default.
- W2084978346 hasConceptScore W2084978346C2778815084 @default.
- W2084978346 hasConceptScore W2084978346C55493867 @default.
- W2084978346 hasConceptScore W2084978346C71924100 @default.
- W2084978346 hasConceptScore W2084978346C86803240 @default.
- W2084978346 hasLocation W20849783461 @default.
- W2084978346 hasLocation W20849783462 @default.
- W2084978346 hasLocation W20849783463 @default.
- W2084978346 hasLocation W20849783464 @default.
- W2084978346 hasOpenAccess W2084978346 @default.
- W2084978346 hasPrimaryLocation W20849783461 @default.
- W2084978346 hasRelatedWork W1986872942 @default.
- W2084978346 hasRelatedWork W2033857640 @default.
- W2084978346 hasRelatedWork W2047746756 @default.
- W2084978346 hasRelatedWork W2139988374 @default.
- W2084978346 hasRelatedWork W2312471842 @default.
- W2084978346 hasRelatedWork W2386365961 @default.
- W2084978346 hasRelatedWork W2400752963 @default.
- W2084978346 hasRelatedWork W2401729949 @default.
- W2084978346 hasRelatedWork W2419144876 @default.
- W2084978346 hasRelatedWork W72381741 @default.
- W2084978346 isParatext "false" @default.
- W2084978346 isRetracted "false" @default.
- W2084978346 magId "2084978346" @default.
- W2084978346 workType "article" @default.