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• W2084979092 abstract "Background: Exposure to stress during adolescence is known to be a risk factor for alcohol‐use and anxiety disorders. This study examined the effects of footshock stress during adolescence on subsequent alcohol drinking in male and female mice selectively bred for high‐alcohol preference (HAP1 lines). Acoustic startle responses and prepulse inhibition (PPI) were also assessed in the absence of, and immediately following, subsequent footshock stress exposures to determine whether a prior history of footshock stress during adolescence would produce enduring effects on anxiety‐related behavior and sensorimotor gating. Methods: Alcohol‐naïve, adolescent (male, n = 27; female, n = 23) and adult (male, n = 30; female, n = 30) HAP1 mice were randomly assigned to a stress or no stress group. The study consisted of 5 phases: (1) 10 consecutive days of exposure to a 30‐minute footshock session, (2) 1 startle test, (3) one 30‐minute footshock session immediately followed by 1 startle test, (4) 30 days of free‐choice alcohol consumption, and (5) one 30‐minute footshock session immediately followed by 1 startle test. Results: Footshock stress exposure during adolescence, but not adulthood, robustly increased alcohol drinking behavior in both male and female HAP1 mice. Before alcohol drinking, females in both the adolescent and adult stress groups showed greater startle in phases 2 and 3; whereas males in the adolescent stress group showed greater startle only in phase 3. After alcohol drinking, in phase 5, enhanced startle was no longer apparent in any stress group. Males in the adult stress group showed reduced startle in phases 2 and 5. PPI was generally unchanged, except that males in the adolescent stress group showed increased PPI in phase 3 and females in the adolescent stress group showed decreased PPI in phase 5. Conclusions: Adolescent HAP1 mice appear to be more vulnerable to the effects of footshock stress than adult mice, as manifested by increased alcohol drinking and anxiety‐related behavior in adulthood. These results in mice suggest that stress exposure during adolescence may increase the risk for developing an alcohol‐use and/or anxiety disorder in individuals with a genetic predisposition toward high alcohol consumption." @default.
• W2084979092 created "2016-06-24" @default.
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• W2084979092 date "2008-09-17" @default.
• W2084979092 modified "2023-10-15" @default.
• W2084979092 title "Age- and Sex-Dependent Effects of Footshock Stress on Subsequent Alcohol Drinking and Acoustic Startle Behavior in Mice Selectively Bred for High-Alcohol Preference" @default.
• W2084979092 cites W1501762129 @default.
• W2084979092 cites W1593390858 @default.
• W2084979092 cites W1730717983 @default.
• W2084979092 cites W1954419420 @default.
• W2084979092 cites W1965374922 @default.
• W2084979092 cites W1966656140 @default.
• W2084979092 cites W1971084704 @default.
• W2084979092 cites W1972345135 @default.
• W2084979092 cites W1973308205 @default.
• W2084979092 cites W1976934495 @default.
• W2084979092 cites W1977565766 @default.
• W2084979092 cites W1979084804 @default.
• W2084979092 cites W1981707861 @default.
• W2084979092 cites W1984346427 @default.
• W2084979092 cites W1985532399 @default.
• W2084979092 cites W1985645068 @default.
• W2084979092 cites W1989416066 @default.
• W2084979092 cites W1994716040 @default.
• W2084979092 cites W1996765130 @default.
• W2084979092 cites W2001503813 @default.
• W2084979092 cites W2002344122 @default.
• W2084979092 cites W2005309639 @default.
• W2084979092 cites W2007389207 @default.
• W2084979092 cites W2013117639 @default.
• W2084979092 cites W2017154390 @default.
• W2084979092 cites W2019741387 @default.
• W2084979092 cites W2021387706 @default.
• W2084979092 cites W2021999592 @default.
• W2084979092 cites W2028147063 @default.
• W2084979092 cites W2028299419 @default.
• W2084979092 cites W2028994085 @default.
• W2084979092 cites W2038532801 @default.
• W2084979092 cites W2039736743 @default.
• W2084979092 cites W2039856816 @default.
• W2084979092 cites W2043961643 @default.
• W2084979092 cites W2046340433 @default.
• W2084979092 cites W2049504595 @default.
• W2084979092 cites W2051761307 @default.
• W2084979092 cites W2054607226 @default.
• W2084979092 cites W2055475051 @default.
• W2084979092 cites W2059134061 @default.
• W2084979092 cites W2060825940 @default.
• W2084979092 cites W2060884332 @default.
• W2084979092 cites W2060973139 @default.
• W2084979092 cites W2062636872 @default.
• W2084979092 cites W2064278932 @default.
• W2084979092 cites W2069417933 @default.
• W2084979092 cites W2072156635 @default.
• W2084979092 cites W2074132525 @default.
• W2084979092 cites W2076695658 @default.
• W2084979092 cites W2080308136 @default.
• W2084979092 cites W2082068743 @default.
• W2084979092 cites W2087287750 @default.
• W2084979092 cites W2087641524 @default.
• W2084979092 cites W2088750047 @default.
• W2084979092 cites W2090566158 @default.
• W2084979092 cites W2090762149 @default.
• W2084979092 cites W2091801114 @default.
• W2084979092 cites W2092069001 @default.
• W2084979092 cites W2096313349 @default.
• W2084979092 cites W2097427330 @default.
• W2084979092 cites W2101759809 @default.
• W2084979092 cites W2109879769 @default.
• W2084979092 cites W2112860638 @default.
• W2084979092 cites W2122953373 @default.
• W2084979092 cites W2124876944 @default.
• W2084979092 cites W2127504265 @default.
• W2084979092 cites W2127857578 @default.
• W2084979092 cites W2141493210 @default.
• W2084979092 cites W2153795414 @default.
• W2084979092 cites W230715885 @default.
• W2084979092 cites W4321429542 @default.
• W2084979092 doi "https://doi.org/10.1111/j.1530-0277.2008.00763.x" @default.
• W2084979092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4426867" @default.
• W2084979092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18652593" @default.
• W2084979092 hasPublicationYear "2008" @default.
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