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• W2084980123 abstract "Using 2,8-bis(trifluoromethyl)quinoline, the pharmacophore of mefloquine, as scaffold, eleven novel triazole-linked compounds have been synthesised by the application of CuAAC chemistry. The in vitro biological activity of the compounds on the Plasmodium falciparum chloroquine-sensitive strain NF54 was then determined. The compounds all showed IC50s in the lower μM range with (1R,3S,5R)-N-{[1-(2,8-bis(trifluoromethyl)quinoline-4-yl)-1H-1,2,3-triazol-4-yl]methyl}adamantan-2-amine (29) exhibiting the best activity of 1.00 μM." @default.
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• W2084980123 date "2014-12-01" @default.
• W2084980123 modified "2023-09-30" @default.
• W2084980123 title "Synthesis of novel triazole-linked mefloquine derivatives: Biological evaluation against Plasmodium falciparum" @default.
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• W2084980123 doi "https://doi.org/10.1016/j.bmcl.2014.10.015" @default.
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