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- W2084982956 abstract "Effect of Ni 2+ on Zn 2+ -induced potentiation of twitch tension was studied electrophysiologically in the toe muscle fibers of Rana catesbeiana. The major findings of this investigation are as follows. When 2 mM Ni 2+ was applied to fibers in a normal Ringer's solution containing 50 μM Zn 2+ (Zn 2+ solution), the Zn 2+ -potentiated twitch tension decreased remarkably to about one-third of that before Ni 2+ treatment. This concentration of Ni 2+ caused a 23% decrease in the duration of action potential which had been prolonged by Zn 2+ (6.61–5.09 ms). Ni 2+ (2 mM) added to normal Ringer's solution led to increases of about 30 and 42% in twitch tension and in the duration of action potential, respectively. A slight increase in the mechanical threshold was induced by 2 mM Ni 2+ . The inhibitory action of Ni 2+ on the twitch tension in Zn 2+ solution was larger than that in the case of tetanus tension. Diltiazem (40 μM), aCa 2+ channel blocker, did not inhibit the twitch tension potentiated in Zn 2+ solution. These results suggest that the decrease in Zn 2+ -potentiated twitch tension by Ni 2+ may possibly derive from impairment of the propagation of action potential along the T tubules." @default.
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- W2084982956 date "1986-05-01" @default.
- W2084982956 modified "2023-09-27" @default.
- W2084982956 title "Inhibition of Zn2+-induced potentiation of twitch tension by Ni2+ in frog muscle" @default.
- W2084982956 doi "https://doi.org/10.1139/y86-104" @default.
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