FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084994912> ?p ?o ?g. }

• W2084994912 endingPage "F423" @default.
• W2084994912 startingPage "F417" @default.
• W2084994912 abstract "Although glycine prevents renal tubular cell injury in vitro, its effect in vivo is not clear. The purpose of this study was to investigate whether a bolus injection of glycine given before reperfusion plus continuous dietary supplementation afterward would reduce renal injury caused by ischemia-reperfusion. Female Sprague-Dawley rats received a semisynthetic powdered diet containing 5% glycine and 15% casein (glycine group) or 20% casein (control group). Two days later, renal ischemia was produced by cross-clamping the left renal vessels for 15 min, followed by reperfusion. The right kidney was removed before reperfusion. The postischemic glomerular filtration rate (GFR) showed that renal function was less impaired and recovered more quickly in rats receiving glycine. For example, at day 7, GFR in controls (0.31 +/- 0.03 ml x min(-1) x 100 g(-1)) was about one-half that of glycine-treated rats (0.61 +/- 0.06 ml x min(-1) x 100 g(-1), P < 0.05). Furthermore, tubular injury and cast formation observed in controls was minimized by glycine (pathology score, 3.2 +/- 0.4 vs. 1.0 +/- 0.4, P < 0.05). Urinary lactate dehydrogenase (LDH) concentration was elevated by ischemia-reperfusion in the control group (260 +/- 22 U/l), but values were significantly lower by about fourfold (60 +/- 30 U/l) in glycine-fed rats. Similarly, free radical production in urine was significantly lower in glycine-treated animals. Importantly, on postischemic day 1, binding of pimonidazole, an in vivo hypoxia marker, was increased in the outer medulla in controls; however, this phenomenon was prevented by glycine. Two weeks later, mild leukocyte infiltration and interstitial fibrosis were still observed in controls, but not in kidneys from glycine-treated rats. In conclusion, these results indicate that administration of glycine indeed reduces mild ischemia-reperfusion injury in the kidney in vivo, in part by decreasing initial damage and preventing chronic hypoxia." @default.
• W2084994912 created "2016-06-24" @default.
• W2084994912 creator A5015414029 @default.
• W2084994912 creator A5016569030 @default.
• W2084994912 creator A5019868317 @default.
• W2084994912 creator A5021887754 @default.
• W2084994912 creator A5023085512 @default.
• W2084994912 creator A5024633392 @default.
• W2084994912 creator A5044918167 @default.
• W2084994912 creator A5076820734 @default.
• W2084994912 creator A5081636513 @default.
• W2084994912 creator A5084489186 @default.
• W2084994912 date "2002-03-01" @default.
• W2084994912 modified "2023-10-06" @default.
• W2084994912 title "Protective effect of glycine on renal injury induced by ischemia-reperfusion in vivo" @default.
• W2084994912 cites W1778687422 @default.
• W2084994912 cites W1970680973 @default.
• W2084994912 cites W1979501223 @default.
• W2084994912 cites W1983909430 @default.
• W2084994912 cites W1987380508 @default.
• W2084994912 cites W1987943363 @default.
• W2084994912 cites W2013439461 @default.
• W2084994912 cites W2017532881 @default.
• W2084994912 cites W2027917795 @default.
• W2084994912 cites W2028475298 @default.
• W2084994912 cites W2031524509 @default.
• W2084994912 cites W2063466980 @default.
• W2084994912 cites W2067447636 @default.
• W2084994912 cites W2067656659 @default.
• W2084994912 cites W2067709564 @default.
• W2084994912 cites W2074976340 @default.
• W2084994912 cites W2077899697 @default.
• W2084994912 cites W2078570634 @default.
• W2084994912 cites W2090262709 @default.
• W2084994912 cites W2092416123 @default.
• W2084994912 cites W2093525170 @default.
• W2084994912 cites W2097744068 @default.
• W2084994912 cites W2111474716 @default.
• W2084994912 cites W2125229121 @default.
• W2084994912 cites W2135016146 @default.
• W2084994912 cites W2138168436 @default.
• W2084994912 cites W2139723538 @default.
• W2084994912 cites W2397768717 @default.
• W2084994912 cites W2413291006 @default.
• W2084994912 cites W2470059529 @default.
• W2084994912 doi "https://doi.org/10.1152/ajprenal.00011.2001" @default.
• W2084994912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11832421" @default.
• W2084994912 hasPublicationYear "2002" @default.
• W2084994912 type Work @default.
• W2084994912 sameAs 2084994912 @default.
• W2084994912 citedByCount "66" @default.
• W2084994912 countsByYear W20849949122012 @default.
• W2084994912 countsByYear W20849949122013 @default.
• W2084994912 countsByYear W20849949122014 @default.
• W2084994912 countsByYear W20849949122015 @default.
• W2084994912 countsByYear W20849949122016 @default.
• W2084994912 countsByYear W20849949122017 @default.
• W2084994912 countsByYear W20849949122018 @default.
• W2084994912 countsByYear W20849949122019 @default.
• W2084994912 countsByYear W20849949122020 @default.
• W2084994912 countsByYear W20849949122021 @default.
• W2084994912 countsByYear W20849949122022 @default.
• W2084994912 countsByYear W20849949122023 @default.
• W2084994912 crossrefType "journal-article" @default.
• W2084994912 hasAuthorship W2084994912A5015414029 @default.
• W2084994912 hasAuthorship W2084994912A5016569030 @default.
• W2084994912 hasAuthorship W2084994912A5019868317 @default.
• W2084994912 hasAuthorship W2084994912A5021887754 @default.
• W2084994912 hasAuthorship W2084994912A5023085512 @default.
• W2084994912 hasAuthorship W2084994912A5024633392 @default.
• W2084994912 hasAuthorship W2084994912A5044918167 @default.
• W2084994912 hasAuthorship W2084994912A5076820734 @default.
• W2084994912 hasAuthorship W2084994912A5081636513 @default.
• W2084994912 hasAuthorship W2084994912A5084489186 @default.
• W2084994912 hasConcept C126322002 @default.
• W2084994912 hasConcept C126894567 @default.
• W2084994912 hasConcept C134018914 @default.
• W2084994912 hasConcept C150903083 @default.
• W2084994912 hasConcept C159641895 @default.
• W2084994912 hasConcept C181199279 @default.
• W2084994912 hasConcept C185592680 @default.
• W2084994912 hasConcept C207001950 @default.
• W2084994912 hasConcept C2777318727 @default.
• W2084994912 hasConcept C2777756961 @default.
• W2084994912 hasConcept C2780091579 @default.
• W2084994912 hasConcept C2780114680 @default.
• W2084994912 hasConcept C2780721119 @default.
• W2084994912 hasConcept C515207424 @default.
• W2084994912 hasConcept C541997718 @default.
• W2084994912 hasConcept C55493867 @default.
• W2084994912 hasConcept C71924100 @default.
• W2084994912 hasConcept C86803240 @default.
• W2084994912 hasConceptScore W2084994912C126322002 @default.
• W2084994912 hasConceptScore W2084994912C126894567 @default.
• W2084994912 hasConceptScore W2084994912C134018914 @default.
• W2084994912 hasConceptScore W2084994912C150903083 @default.
• W2084994912 hasConceptScore W2084994912C159641895 @default.
• W2084994912 hasConceptScore W2084994912C181199279 @default.

• next