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- W2085010658 abstract "Abstract Rats immunized with adrenal cortical tissue in complete Freund's adjuvant developed adrenocortical insufficiency as evidenced by failure to gain weight, hypoglycemia during fasting, an increased rate of water and salt excretion when placed on a salt-free diet, and a reduced corticosterone content of the blood plasma. These functional disturbances were reflected in degenerative changes throughout the adrenal cortex, as manifested by vacuolization of the cytoplasma and changes in the mitochondria. The presence of isoantibodies against adrenocortical tissue was demonstrated by immuno-diffusion tests. There was also an increased gamma globulin content of the serum and infiltration of the affected tissues by mononuclear cells, suggestive of an autoimmune reaction. Rats immunized with adrenomedullary tissue developed degenerative changes in the chromaphil cells and a mild elevation in blood pressure, but no evidence of anatomic or functional disturbances of the cortex." @default.
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- W2085010658 date "1968-08-01" @default.
- W2085010658 modified "2023-09-27" @default.
- W2085010658 title "Induction of adrenal insufficiency in the rat by sensitization with homologous tissue" @default.
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- W2085010658 doi "https://doi.org/10.1016/0026-0495(68)90056-5" @default.
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