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• W2085016384 startingPage "1005" @default.
• W2085016384 abstract "Inhibitory receptors expressed on natural killer (NK) cells abrogate positive signals upon binding corresponding major histocompatibility complex (MHC) class I molecules on various target cells. By directly micromanipulating the effector–target cell encounter using an optical tweezers system which allowed temporal and spatial control, we demonstrate that Ly49–MHC class I interactions prevent characteristic cellular responses in NK cells upon binding to target cells. Furthermore, using this system, we directly demonstrate that an NK cell already bound to a resistant target cell may simultaneously bind and kill a susceptible target cell. Thus, although Ly49-mediated inhibitory signals can prevent many types of effector responses, they do not globally inhibit cellular function, but rather the inhibitory signal is spatially restricted towards resistant targets." @default.
• W2085016384 created "2016-06-24" @default.
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• W2085016384 date "1999-10-04" @default.
• W2085016384 modified "2023-10-18" @default.
• W2085016384 title "Inhibitory Receptors Alter Natural Killer Cell Interactions with Target Cells Yet Allow Simultaneous Killing of Susceptible Targets" @default.
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• W2085016384 doi "https://doi.org/10.1084/jem.190.7.1005" @default.
• W2085016384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2195645" @default.
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