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- W2085017133 abstract "Purpose of review The appearance of scavenger receptor class B type I (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) in macrophages and liver implicates these transporters in different stages of reverse cholesterol transport. This review focuses on the role of SR-BI and ABCA1 in reverse cholesterol transport in the context of atherosclerotic lesion development. Recent findings Recent studies indicate that hepatic expression of ABCA1 and SR-BI is important for the generation of nascent HDL and the delivery of HDL cholesteryl esters to the liver, respectively. Although macrophage SR-BI and ABCA1 do not contribute significantly to circulating HDL levels, the perpetual cycle of HDL lipidation and delipidation by the liver ensures the availability of acceptors for cholesterol efflux that maintain cholesterol homeostasis in arterial macrophages, thereby reducing atherogenesis. In addition to its established role in the selective uptake of HDL cholesteryl esters, there is now evidence that hepatic SR-BI facilitates postprandial lipid metabolism, and that hepatic secretion of VLDL is dependent on ABCA1-mediated nascent HDL formation. Thus, remnant and HDL metabolism are more intimately intertwined in hepatic lipid metabolism than has previously been appreciated. Summary Recent advances in the understanding of the role of ABCA1 and SR-BI in HDL metabolism and their atheroprotective properties indicate the significant potential of modulating ABCA1 and SR-BI expression in both arterial wall macrophages and the liver for the treatment of atherosclerotic coronary artery disease." @default.
- W2085017133 created "2016-06-24" @default.
- W2085017133 creator A5014696236 @default.
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- W2085017133 creator A5024733637 @default.
- W2085017133 creator A5031525436 @default.
- W2085017133 creator A5036385467 @default.
- W2085017133 date "2005-06-01" @default.
- W2085017133 modified "2023-10-12" @default.
- W2085017133 title "Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis" @default.
- W2085017133 cites W1574380753 @default.
- W2085017133 cites W1591670239 @default.
- W2085017133 cites W1596816338 @default.
- W2085017133 cites W1607399348 @default.
- W2085017133 cites W1860908381 @default.
- W2085017133 cites W1901163999 @default.
- W2085017133 cites W1966609176 @default.
- W2085017133 cites W1974864595 @default.
- W2085017133 cites W1977504620 @default.
- W2085017133 cites W1985170971 @default.
- W2085017133 cites W1987401504 @default.
- W2085017133 cites W1987525850 @default.
- W2085017133 cites W1988532263 @default.
- W2085017133 cites W1993028907 @default.
- W2085017133 cites W1993473307 @default.
- W2085017133 cites W1995706082 @default.
- W2085017133 cites W1997678048 @default.
- W2085017133 cites W1999163997 @default.
- W2085017133 cites W2009636256 @default.
- W2085017133 cites W2013282518 @default.
- W2085017133 cites W2014317320 @default.
- W2085017133 cites W2015805615 @default.
- W2085017133 cites W2015849111 @default.
- W2085017133 cites W2016597009 @default.
- W2085017133 cites W2017120858 @default.
- W2085017133 cites W2017228587 @default.
- W2085017133 cites W2020892886 @default.
- W2085017133 cites W2022376333 @default.
- W2085017133 cites W2024131238 @default.
- W2085017133 cites W2025197525 @default.
- W2085017133 cites W2026658644 @default.
- W2085017133 cites W2027338183 @default.
- W2085017133 cites W2030479102 @default.
- W2085017133 cites W2038919289 @default.
- W2085017133 cites W2039855201 @default.
- W2085017133 cites W2040571306 @default.
- W2085017133 cites W2040915824 @default.
- W2085017133 cites W2042186001 @default.
- W2085017133 cites W2043832254 @default.
- W2085017133 cites W2046741089 @default.
- W2085017133 cites W2047330360 @default.
- W2085017133 cites W2052117565 @default.
- W2085017133 cites W2056452930 @default.
- W2085017133 cites W2058321605 @default.
- W2085017133 cites W2062030534 @default.
- W2085017133 cites W2063358283 @default.
- W2085017133 cites W2065689560 @default.
- W2085017133 cites W2066298745 @default.
- W2085017133 cites W2066557706 @default.
- W2085017133 cites W2069027872 @default.
- W2085017133 cites W2069421471 @default.
- W2085017133 cites W2069421633 @default.
- W2085017133 cites W2069540409 @default.
- W2085017133 cites W2073308465 @default.
- W2085017133 cites W2076490603 @default.
- W2085017133 cites W2077403992 @default.
- W2085017133 cites W2081695716 @default.
- W2085017133 cites W2087250632 @default.
- W2085017133 cites W2089331280 @default.
- W2085017133 cites W2092270878 @default.
- W2085017133 cites W2092461792 @default.
- W2085017133 cites W2093099491 @default.
- W2085017133 cites W2094768566 @default.
- W2085017133 cites W2097583089 @default.
- W2085017133 cites W2098562504 @default.
- W2085017133 cites W2098616846 @default.
- W2085017133 cites W2099335802 @default.
- W2085017133 cites W2102642680 @default.
- W2085017133 cites W2103714932 @default.
- W2085017133 cites W2104399391 @default.
- W2085017133 cites W2106217522 @default.
- W2085017133 cites W2106452452 @default.
- W2085017133 cites W2107348072 @default.
- W2085017133 cites W2111222992 @default.
- W2085017133 cites W2112488622 @default.
- W2085017133 cites W2113602208 @default.
- W2085017133 cites W2120220517 @default.
- W2085017133 cites W2122062568 @default.
- W2085017133 cites W2125813945 @default.
- W2085017133 cites W2126076118 @default.
- W2085017133 cites W2128738849 @default.
- W2085017133 cites W2128986402 @default.
- W2085017133 cites W2130086266 @default.
- W2085017133 cites W2130877850 @default.
- W2085017133 cites W2131206808 @default.
- W2085017133 cites W2132512455 @default.
- W2085017133 cites W2133238095 @default.
- W2085017133 cites W2137085147 @default.