FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085030879> ?p ?o ?g. }

• W2085030879 endingPage "82" @default.
• W2085030879 startingPage "76" @default.
• W2085030879 abstract "This study examines the effects of three calcium channel blockers (verapamil, nifedipine and diltiazem) on isolated rat hepatocytes exposed to ethanol. In the first part of our study, hepatocytes were incubated with increasing concentrations of ethanol (100, 300, 500, 1000 mM) for varying times. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) release were measured to evaluate the cytotoxic effects of ethanol. The concentration of 300 mM and time of incubation of 45 min were chosen for cytoprotection experiments in which calcium channel blockers, at two different concentrations, were added to the medium 30 min prior to the addition of ethanol. ALT, AST and LDH release as well as lipid peroxidation and cellular reduced glutathione (GSH) were measured. Nifedipine and verapamil (25 microM) reduced ALT, AST and LDH activities. The highest dose of diltiazem (50 microM) was more effective than the lowest one (25 microM). Ethanol caused a significant depletion of cellular GSH content as well as a moderate enhancement of lipid peroxidation. While none of the three calcium channel blockers was able to restore the decrease in GSH levels, diltiazem (25 microM) and nifedipine (50 microM) showed the greatest effect, significantly reducing lipid peroxidation." @default.
• W2085030879 created "2016-06-24" @default.
• W2085030879 creator A5015483969 @default.
• W2085030879 creator A5019453524 @default.
• W2085030879 creator A5050648353 @default.
• W2085030879 creator A5082185730 @default.
• W2085030879 date "2008-12-10" @default.
• W2085030879 modified "2023-09-23" @default.
• W2085030879 title "Hepatotoxicity of ethanol: protective effect of calcium channel blockers in isolated hepatocytes" @default.
• W2085030879 cites W1543008345 @default.
• W2085030879 cites W1593868340 @default.
• W2085030879 cites W1600304436 @default.
• W2085030879 cites W1968381948 @default.
• W2085030879 cites W1972150732 @default.
• W2085030879 cites W1988278312 @default.
• W2085030879 cites W1992058399 @default.
• W2085030879 cites W1992987002 @default.
• W2085030879 cites W1994032728 @default.
• W2085030879 cites W2003881446 @default.
• W2085030879 cites W2005991568 @default.
• W2085030879 cites W2010425706 @default.
• W2085030879 cites W2020410905 @default.
• W2085030879 cites W2023920680 @default.
• W2085030879 cites W2026261400 @default.
• W2085030879 cites W2043609186 @default.
• W2085030879 cites W2044502222 @default.
• W2085030879 cites W2048107324 @default.
• W2085030879 cites W2048755716 @default.
• W2085030879 cites W2052731507 @default.
• W2085030879 cites W2053438154 @default.
• W2085030879 cites W2054706982 @default.
• W2085030879 cites W2061912748 @default.
• W2085030879 cites W2083588872 @default.
• W2085030879 cites W2086173758 @default.
• W2085030879 cites W2087471419 @default.
• W2085030879 cites W2124816752 @default.
• W2085030879 cites W2129031038 @default.
• W2085030879 cites W2134031163 @default.
• W2085030879 cites W2147333402 @default.
• W2085030879 cites W2334886837 @default.
• W2085030879 doi "https://doi.org/10.1111/j.1600-0676.1997.tb00784.x" @default.
• W2085030879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9138276" @default.
• W2085030879 hasPublicationYear "2008" @default.
• W2085030879 type Work @default.
• W2085030879 sameAs 2085030879 @default.
• W2085030879 citedByCount "22" @default.
• W2085030879 countsByYear W20850308792012 @default.
• W2085030879 countsByYear W20850308792014 @default.
• W2085030879 countsByYear W20850308792018 @default.
• W2085030879 countsByYear W20850308792019 @default.
• W2085030879 countsByYear W20850308792022 @default.
• W2085030879 crossrefType "journal-article" @default.
• W2085030879 hasAuthorship W2085030879A5015483969 @default.
• W2085030879 hasAuthorship W2085030879A5019453524 @default.
• W2085030879 hasAuthorship W2085030879A5050648353 @default.
• W2085030879 hasAuthorship W2085030879A5082185730 @default.
• W2085030879 hasConcept C134018914 @default.
• W2085030879 hasConcept C153461711 @default.
• W2085030879 hasConcept C178790620 @default.
• W2085030879 hasConcept C181199279 @default.
• W2085030879 hasConcept C185592680 @default.
• W2085030879 hasConcept C202751555 @default.
• W2085030879 hasConcept C2776200302 @default.
• W2085030879 hasConcept C2776741139 @default.
• W2085030879 hasConcept C2777022698 @default.
• W2085030879 hasConcept C2777318727 @default.
• W2085030879 hasConcept C2778004101 @default.
• W2085030879 hasConcept C2779066535 @default.
• W2085030879 hasConcept C2780161600 @default.
• W2085030879 hasConcept C2780829032 @default.
• W2085030879 hasConcept C29730261 @default.
• W2085030879 hasConcept C519063684 @default.
• W2085030879 hasConcept C538909803 @default.
• W2085030879 hasConcept C55493867 @default.
• W2085030879 hasConcept C71924100 @default.
• W2085030879 hasConcept C85520022 @default.
• W2085030879 hasConcept C98274493 @default.
• W2085030879 hasConceptScore W2085030879C134018914 @default.
• W2085030879 hasConceptScore W2085030879C153461711 @default.
• W2085030879 hasConceptScore W2085030879C178790620 @default.
• W2085030879 hasConceptScore W2085030879C181199279 @default.
• W2085030879 hasConceptScore W2085030879C185592680 @default.
• W2085030879 hasConceptScore W2085030879C202751555 @default.
• W2085030879 hasConceptScore W2085030879C2776200302 @default.
• W2085030879 hasConceptScore W2085030879C2776741139 @default.
• W2085030879 hasConceptScore W2085030879C2777022698 @default.
• W2085030879 hasConceptScore W2085030879C2777318727 @default.
• W2085030879 hasConceptScore W2085030879C2778004101 @default.
• W2085030879 hasConceptScore W2085030879C2779066535 @default.
• W2085030879 hasConceptScore W2085030879C2780161600 @default.
• W2085030879 hasConceptScore W2085030879C2780829032 @default.
• W2085030879 hasConceptScore W2085030879C29730261 @default.
• W2085030879 hasConceptScore W2085030879C519063684 @default.
• W2085030879 hasConceptScore W2085030879C538909803 @default.
• W2085030879 hasConceptScore W2085030879C55493867 @default.
• W2085030879 hasConceptScore W2085030879C71924100 @default.
• W2085030879 hasConceptScore W2085030879C85520022 @default.
• W2085030879 hasConceptScore W2085030879C98274493 @default.

• next