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- W2085035687 abstract "Abstract Significant RNA synthesis can be demonstrated in surviving pig-, sheep-, and calf-thyroid slices in vitro using [14C]formate as a precursor. DNA formation is much less active. In the calf thyroid purine synthesis is very rapid in vitro, and 44% of the 14C label is incorporated into the C-8 position of RNA adenine indicating that there is significant purine formation by way of the full de novo pathway. 5-Amino-4-imidazole carboxamide caused marked stimulation of purine formation and 5-amino-4-imidazole carboxamide ribonucleoside is even more effective. Glucose alone causes a small increment in purine synthesis, but in the presence of 5-amino-4-imidazole carboxamide, glucose causes a similar increase to that produced by 5-amino-4-imidazole carboxamide ribonucleoside." @default.
- W2085035687 created "2016-06-24" @default.
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- W2085035687 date "1962-10-01" @default.
- W2085035687 modified "2023-09-27" @default.
- W2085035687 title "Nucleic acid synthesis in the thyroid" @default.
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- W2085035687 doi "https://doi.org/10.1016/0926-6550(62)90104-4" @default.
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