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- W2085060041 abstract "The recent successes of adoptive T-cell immunotherapy for the treatment of hematologic malignancies have highlighted the need for manufacturing processes that are robust and scalable for product commercialization. Here we review some of the more outstanding issues surrounding commercial scale manufacturing of personalized-adoptive T-cell medicinal products. These include closed system operations, improving process robustness and simplifying work flows, reducing labor intensity by implementing process automation, scalability and cost, as well as appropriate testing and tracking of products, all while maintaining strict adherence to Current Good Manufacturing Practices and regulatory guidelines. A decentralized manufacturing model is proposed, where in the future patients' cells could be processed at the point-of-care in the hospital." @default.
- W2085060041 created "2016-06-24" @default.
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- W2085060041 date "2015-01-23" @default.
- W2085060041 modified "2023-10-10" @default.
- W2085060041 title "Towards a commercial process for the manufacture of genetically modified T cells for therapy" @default.
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- W2085060041 doi "https://doi.org/10.1038/cgt.2014.78" @default.
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