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• W2085066394 abstract "Unactivated Csp3−H bonds are ubiquitous in organic chemicals and hydrocarbon feedstocks. However, these resources remain largely untapped, and the development of efficient homogeneous methods for hydrocarbon functionalization by C−H activation is an attractive and unresolved challenge for synthetic chemists. Transition-metal catalysis offers an attractive possible means for achieving selective, catalytic C−H functionalization given the thermodynamically favorable nature of many desirable partial oxidation schemes and the propensity of transition-metal complexes to cleave C−H bonds. Selective C−H activation, typically by a single cleavage event to produce M−Csp3 products, is possible through myriad reported transition-metal species. In contrast, several recent reports have shown that late transition metals may react with certain substrates to perform multiple C−H activations, generating M═Csp2 complexes for further elaboration. In light of the rich reactivity of metal-bound carbenes, such a route could open a new manifold of reactivity for catalytic C−H functionalization, and we have targeted this strategy in our studies. In this Account, we highlight several early examples of late transition-metal complexes that have been shown to generate metal-bound carbenes by multiple C−H activations and briefly examine factors leading to the selective generation of metal carbenes through this route. Using these reports as a backdrop, we focus on the double C−H activation of ethers and amines at iridium complexes supported by Ozerov’s amidophosphine PNP ligand (PNP = [N(2-PiPr2-4-Me-C6H3)2]−), allowing isolation of unusual square-planar iridium(I) carbenes. These species exhibit reactivity that is distinct from the archetypal Fischer and Schrock designations. We present experimental and theoretical studies showing that, like the classical square-planar iridium(I) organometallics, these complexes are best described as nucleophilic at iridium. We discuss the classification of this reactivity in the context of a scheme originally delineated by Roper. These “Roper-type” carbenes perform a number of multiple-bond metatheses leading to atom and group transfer from electrophilic heterocumulene (e.g., CO2, CS2, PhNCS) and diazo (e.g., N2O, AdN3) reagents. In one instance, we have extended this methodology to a process for catalytic C−H functionalization by a double C−H activation-group transfer process. Although the scope of these reactions is currently limited, these new pathways may find broader utility as the reactivity of late-metal carbenes continues to be explored. Examination of alternative transition metals and supporting ligand sets will certainly be important. Nonetheless, our findings show that carbene generation by double C−H activation is a viable strategy for C−H functionalization, leading to products not accessible through traditional Csp3−H activation pathways." @default.
• W2085066394 created "2016-06-24" @default.
• W2085066394 creator A5038379932 @default.
• W2085066394 creator A5078597191 @default.
• W2085066394 date "2009-07-22" @default.
• W2085066394 modified "2023-10-09" @default.
• W2085066394 title "Late Metal Carbene Complexes Generated by Multiple C−H Activations: Examining the Continuum of M═C Bond Reactivity" @default.
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• W2085066394 doi "https://doi.org/10.1021/ar900103e" @default.
• W2085066394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19624162" @default.
• W2085066394 hasPublicationYear "2009" @default.
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