Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085087397> ?p ?o ?g. }
- W2085087397 endingPage "436" @default.
- W2085087397 startingPage "430" @default.
- W2085087397 abstract "Inflammation is a hallmark of inflammatory bowel disease (IBD), and elevation of cAMP levels can inhibit the pro-inflammatory and tissue-destructive properties of leukocytes. Phosphodiesterase 4 (PDE4) is the predominant enzyme that metabolizes cAMP in inflammatory cells, and the anti-inflammatory and immunomodulatory potential of PDE4 inhibitors in human leukocytes, endothelium and epithelium is well documented. Although PDE4 inhibitors have been investigated as treatments for several inflammatory diseases, this has focused mainly on asthma and chronic obstructive disease (COPD). Historically, their clinical utility has been limited by nausea and emesis. However, the PDE4 inhibitors cilomilast and roflumilast have recently shown efficacy in asthma and COPD, with a reduced propensity to cause nausea and emesis. In this review, we summarize for the first time the evidence that PDE4 inhibitors might have therapeutic benefit in IBD, and discuss mechanisms of action beyond the inhibition of inflammatory cells." @default.
- W2085087397 created "2016-06-24" @default.
- W2085087397 creator A5027636877 @default.
- W2085087397 creator A5086836417 @default.
- W2085087397 date "2004-08-01" @default.
- W2085087397 modified "2023-10-16" @default.
- W2085087397 title "PDE4 inhibition: a novel approach for the treatment of inflammatory bowel disease" @default.
- W2085087397 cites W1491959113 @default.
- W2085087397 cites W1516500578 @default.
- W2085087397 cites W1640670825 @default.
- W2085087397 cites W18133911 @default.
- W2085087397 cites W1901931884 @default.
- W2085087397 cites W1964749390 @default.
- W2085087397 cites W1967882515 @default.
- W2085087397 cites W1969241777 @default.
- W2085087397 cites W1976082335 @default.
- W2085087397 cites W1978095676 @default.
- W2085087397 cites W1978487251 @default.
- W2085087397 cites W1990687490 @default.
- W2085087397 cites W1994226794 @default.
- W2085087397 cites W1995642722 @default.
- W2085087397 cites W1996164132 @default.
- W2085087397 cites W1998273056 @default.
- W2085087397 cites W1999964462 @default.
- W2085087397 cites W2003860120 @default.
- W2085087397 cites W2005590621 @default.
- W2085087397 cites W2012016179 @default.
- W2085087397 cites W2013686136 @default.
- W2085087397 cites W2024162533 @default.
- W2085087397 cites W2028882736 @default.
- W2085087397 cites W2036958200 @default.
- W2085087397 cites W2037685537 @default.
- W2085087397 cites W2046313504 @default.
- W2085087397 cites W2058640545 @default.
- W2085087397 cites W2067744085 @default.
- W2085087397 cites W2068657848 @default.
- W2085087397 cites W2070124199 @default.
- W2085087397 cites W2071508654 @default.
- W2085087397 cites W2073441678 @default.
- W2085087397 cites W2077770819 @default.
- W2085087397 cites W2092218279 @default.
- W2085087397 cites W2097176818 @default.
- W2085087397 cites W2108305557 @default.
- W2085087397 cites W2116095750 @default.
- W2085087397 cites W2119219180 @default.
- W2085087397 cites W2120702538 @default.
- W2085087397 cites W2126911875 @default.
- W2085087397 cites W2145392985 @default.
- W2085087397 cites W2148557985 @default.
- W2085087397 cites W2339839448 @default.
- W2085087397 cites W2400243365 @default.
- W2085087397 cites W3092133778 @default.
- W2085087397 cites W4251167677 @default.
- W2085087397 cites W4256102116 @default.
- W2085087397 cites W4292198229 @default.
- W2085087397 cites W4313335967 @default.
- W2085087397 cites W4313376856 @default.
- W2085087397 cites W60391424 @default.
- W2085087397 doi "https://doi.org/10.1016/j.tips.2004.06.008" @default.
- W2085087397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15276712" @default.
- W2085087397 hasPublicationYear "2004" @default.
- W2085087397 type Work @default.
- W2085087397 sameAs 2085087397 @default.
- W2085087397 citedByCount "81" @default.
- W2085087397 countsByYear W20850873972012 @default.
- W2085087397 countsByYear W20850873972013 @default.
- W2085087397 countsByYear W20850873972015 @default.
- W2085087397 countsByYear W20850873972017 @default.
- W2085087397 countsByYear W20850873972018 @default.
- W2085087397 countsByYear W20850873972019 @default.
- W2085087397 countsByYear W20850873972020 @default.
- W2085087397 countsByYear W20850873972021 @default.
- W2085087397 countsByYear W20850873972022 @default.
- W2085087397 countsByYear W20850873972023 @default.
- W2085087397 crossrefType "journal-article" @default.
- W2085087397 hasAuthorship W2085087397A5027636877 @default.
- W2085087397 hasAuthorship W2085087397A5086836417 @default.
- W2085087397 hasConcept C126322002 @default.
- W2085087397 hasConcept C181199279 @default.
- W2085087397 hasConcept C203014093 @default.
- W2085087397 hasConcept C2776042228 @default.
- W2085087397 hasConcept C2776780178 @default.
- W2085087397 hasConcept C2776914184 @default.
- W2085087397 hasConcept C2777572184 @default.
- W2085087397 hasConcept C2778260677 @default.
- W2085087397 hasConcept C2778926808 @default.
- W2085087397 hasConcept C2779134260 @default.
- W2085087397 hasConcept C2780580376 @default.
- W2085087397 hasConcept C55493867 @default.
- W2085087397 hasConcept C62826618 @default.
- W2085087397 hasConcept C71924100 @default.
- W2085087397 hasConcept C86803240 @default.
- W2085087397 hasConcept C98274493 @default.
- W2085087397 hasConceptScore W2085087397C126322002 @default.
- W2085087397 hasConceptScore W2085087397C181199279 @default.
- W2085087397 hasConceptScore W2085087397C203014093 @default.
- W2085087397 hasConceptScore W2085087397C2776042228 @default.
- W2085087397 hasConceptScore W2085087397C2776780178 @default.