FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085087448> ?p ?o ?g. }

• W2085087448 endingPage "884" @default.
• W2085087448 startingPage "877" @default.
• W2085087448 abstract "✓ Hypoglycemia increases the vulnerability of the perinatal brain to asphyxia, but it is not known if hypoglycemia-induced changes in cerebral hemodynamics and vascular reactivity underlie this vulnerability. This study tested the hypothesis that hypoglycemia exacerbates postischemic hypoperfusion, and impairs postischemic CO 2 reactivity. The authors also examined the hypothesis that postischemic hypoperfusion is associated with a reduction in the interstitial concentration of the vasodilator metabolite adenosine. Global cerebral ischemia of 10 minutes duration was induced in newborn pigs anesthetized with isoflurane by occlusion of subclavian and brachiocephalic arteries; cortical cerebral blood flow (CBF) and interstitial adenosine concentration were evaluated simultaneously using the combined hydrogen clearance/microdialysis technique. Hypoglycemia (blood glucose < 25 mg/dl) was induced by regular insulin (25 IU/kg) administered intravenously 2 hours prior to induction of ischemia. In the eight normoglycemic animals, baseline CBF was 38 ± 4 ml/min/100 gm and baseline adenosine concentration was 1.2 ± 0.1 µM; in the eight hypoglycemic animals, these values were 39% (p < 0.05) and 62% (p < 0.05) greater, respectively, under baseline conditions. At 1 hour of postischemic reperfusion in normoglycemic animals, CBF was reduced 39% relative to the preischemic baseline (p < 0.01), concomitant with a 27% reduction (p < 0.05) in adenosine concentration, suggesting that this lowered concentration may underlie delayed hypoperfusion. These postischemic reductions in CBF and interstitial adenosine concentration were significantly greater in hypoglycemic animals, with CBF and adenosine concentration reduced 70% (p < 0.001) and 71% (p < 0.01), respectively, relative to baseline. In nine animals preischemic reactivity to hypercapnia was unaffected by hypoglycemia. Postischemic hypercapnic reactivity was retained in the eight normoglycemic animals, but was attenuated 73% (p < 0.05) in hypoglycemic animals. Thus, in the newborn pig, hypoglycemia exacerbates postischemic cortical hypoperfusion and impairs postischemic cerebrovascular reactivity to hypercapnia." @default.
• W2085087448 created "2016-06-24" @default.
• W2085087448 creator A5017663015 @default.
• W2085087448 creator A5026047240 @default.
• W2085087448 creator A5026257559 @default.
• W2085087448 creator A5051331574 @default.
• W2085087448 creator A5079864309 @default.
• W2085087448 date "1994-12-01" @default.
• W2085087448 modified "2023-09-23" @default.
• W2085087448 title "Effect of hypoglycemia on postischemic cortical blood flow, hypercapnic reactivity, and interstitial adenosine concentration" @default.
• W2085087448 cites W1964796026 @default.
• W2085087448 cites W1967582148 @default.
• W2085087448 cites W1968179475 @default.
• W2085087448 cites W1973521298 @default.
• W2085087448 cites W1985335901 @default.
• W2085087448 cites W1999625635 @default.
• W2085087448 cites W2008159341 @default.
• W2085087448 cites W2015518389 @default.
• W2085087448 cites W2017491447 @default.
• W2085087448 cites W2026056213 @default.
• W2085087448 cites W2027185685 @default.
• W2085087448 cites W2032237884 @default.
• W2085087448 cites W2034571515 @default.
• W2085087448 cites W2038397802 @default.
• W2085087448 cites W2041623614 @default.
• W2085087448 cites W2044989878 @default.
• W2085087448 cites W2062900910 @default.
• W2085087448 cites W2070028056 @default.
• W2085087448 cites W2076591871 @default.
• W2085087448 cites W2076906897 @default.
• W2085087448 cites W2078171117 @default.
• W2085087448 cites W2078763668 @default.
• W2085087448 cites W2079243523 @default.
• W2085087448 cites W2085974840 @default.
• W2085087448 cites W2088904830 @default.
• W2085087448 cites W2089550627 @default.
• W2085087448 cites W2090437740 @default.
• W2085087448 cites W2093821452 @default.
• W2085087448 cites W2095137556 @default.
• W2085087448 cites W2150852392 @default.
• W2085087448 cites W2164317197 @default.
• W2085087448 cites W2296565555 @default.
• W2085087448 cites W2410952261 @default.
• W2085087448 cites W2417562176 @default.
• W2085087448 cites W2440809498 @default.
• W2085087448 doi "https://doi.org/10.3171/jns.1994.81.6.0877" @default.
• W2085087448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7965118" @default.
• W2085087448 hasPublicationYear "1994" @default.
• W2085087448 type Work @default.
• W2085087448 sameAs 2085087448 @default.
• W2085087448 citedByCount "18" @default.
• W2085087448 countsByYear W20850874482017 @default.
• W2085087448 countsByYear W20850874482019 @default.
• W2085087448 countsByYear W20850874482021 @default.
• W2085087448 countsByYear W20850874482023 @default.
• W2085087448 crossrefType "journal-article" @default.
• W2085087448 hasAuthorship W2085087448A5017663015 @default.
• W2085087448 hasAuthorship W2085087448A5026047240 @default.
• W2085087448 hasAuthorship W2085087448A5026257559 @default.
• W2085087448 hasAuthorship W2085087448A5051331574 @default.
• W2085087448 hasAuthorship W2085087448A5079864309 @default.
• W2085087448 hasConcept C120770815 @default.
• W2085087448 hasConcept C126322002 @default.
• W2085087448 hasConcept C134018914 @default.
• W2085087448 hasConcept C146957229 @default.
• W2085087448 hasConcept C157767197 @default.
• W2085087448 hasConcept C2776991684 @default.
• W2085087448 hasConcept C2779306644 @default.
• W2085087448 hasConcept C2780668416 @default.
• W2085087448 hasConcept C42219234 @default.
• W2085087448 hasConcept C50156730 @default.
• W2085087448 hasConcept C513476851 @default.
• W2085087448 hasConcept C541997718 @default.
• W2085087448 hasConcept C71924100 @default.
• W2085087448 hasConceptScore W2085087448C120770815 @default.
• W2085087448 hasConceptScore W2085087448C126322002 @default.
• W2085087448 hasConceptScore W2085087448C134018914 @default.
• W2085087448 hasConceptScore W2085087448C146957229 @default.
• W2085087448 hasConceptScore W2085087448C157767197 @default.
• W2085087448 hasConceptScore W2085087448C2776991684 @default.
• W2085087448 hasConceptScore W2085087448C2779306644 @default.
• W2085087448 hasConceptScore W2085087448C2780668416 @default.
• W2085087448 hasConceptScore W2085087448C42219234 @default.
• W2085087448 hasConceptScore W2085087448C50156730 @default.
• W2085087448 hasConceptScore W2085087448C513476851 @default.
• W2085087448 hasConceptScore W2085087448C541997718 @default.
• W2085087448 hasConceptScore W2085087448C71924100 @default.
• W2085087448 hasIssue "6" @default.
• W2085087448 hasLocation W20850874481 @default.
• W2085087448 hasLocation W20850874482 @default.
• W2085087448 hasOpenAccess W2085087448 @default.
• W2085087448 hasPrimaryLocation W20850874481 @default.
• W2085087448 hasRelatedWork W1965943749 @default.
• W2085087448 hasRelatedWork W1969081729 @default.
• W2085087448 hasRelatedWork W1992894626 @default.
• W2085087448 hasRelatedWork W2057434408 @default.
• W2085087448 hasRelatedWork W2076974163 @default.
• W2085087448 hasRelatedWork W2080068238 @default.

• next