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• W2085100438 abstract "Injections of GABA (125–500 μg in 1 μl) or muscimol (40–200 ng in 1 μl) into the nucleus accumbens markedly reduced the amphetamine-induced circling of rats with unilateral 6-hydroxydopamine (6-OHDA)-induced lesions of nigrostriatal dopamine neurons. The potency of muscimol was approximately 10 4 times that of GABA. Muscimol exerted a similar effect when injected in a smaller volume (0.5 μl) at a slower rate (0.11 μl/min), a procedure which was shown to reduce the spread of injected [ 3 H]muscimol. Intra-accumbens injections of subconvulsive doses of picrotoxin had no effect on amphetamine-induced circling. Intra-accumbens muscimol (40 ng, 0.5 μl, 0.11 μl/min) also reduced the contralateral circling evoked by apomorphine in rats with unilateral 6-OHDA-induced lesions of the nigrostriatal pathway and bilateral 6-OHDA-induced lesions of the mesolimbic dopamine terminals. These results suggest that GABA-ergic activity in the nucleus accumbens exerts an inhibitory influence on drug-induced circling. At least part of this action is at a step beyond the release of dopamine from mesolimbic terminals." @default.
• W2085100438 created "2016-06-24" @default.
• W2085100438 creator A5008304642 @default.
• W2085100438 creator A5008634258 @default.
• W2085100438 date "1983-09-01" @default.
• W2085100438 modified "2023-09-27" @default.
• W2085100438 title "Inhibition of drug-induced circling by GABA-ergic activity in the nucleus accumbens" @default.
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• W2085100438 doi "https://doi.org/10.1016/0361-9230(83)90167-3" @default.
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