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- W2085102945 abstract "In the present study, grafting technology has been used to develop novel grafted hydrogel beads as controlled drug delivery carriers. The chemical crosslinking and grafting of polyacrylamide onto sodium alginate has been found to be efficient method for the development of new polymeric carrier. The successful crosslinking has been confirmed by Fourier transformed infrared spectroscopy, thermogravimetric analysis, and elemental analysis. The polymeric network of sodium alginate–co-polyacrylamide (NaAlg-g-PAM) has been interlinked by covalent and hydrogen bonds which also strength the gel network. Simple ionotropic gelation method has been used for the preparation of NaAlg-g-PAM hydrogel beads. Its swelling and gelation were dependent on monomer and crosslinker concentrations. Entrapment of the drug moiety (famotidine; an antiulcer drug) within the grafted beads has been confirmed by X-ray powder diffraction and differential scanning calorimetry. More than 75% of drug loading in beads occurred with the increase of monomer and crosslinker concentration. In vitro drug release was found to be sustained up to the 12 h with 80% drug release." @default.
- W2085102945 created "2016-06-24" @default.
- W2085102945 creator A5015596141 @default.
- W2085102945 creator A5047734157 @default.
- W2085102945 date "2012-08-31" @default.
- W2085102945 modified "2023-10-07" @default.
- W2085102945 title "“Development and Evaluation of Sodium Alginate–Polyacrylamide Graft–Co-polymer-Based Stomach Targeted Hydrogels of Famotidine”" @default.
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- W2085102945 doi "https://doi.org/10.1208/s12249-012-9824-1" @default.
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