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- W2085103671 abstract "Background: In mice that are passively sensitized to IgE, cutaneous antigen challenge produces a biphasic response with peaks at 1 and 24 hours after challenge. Objective: We investigated the role of mast cells in the IgE-mediated late-phase reaction in mice. Methods: We histologically and ultrastructurally investigated the morphologic changes of mast cells during the biphasic responses. Results: Degranulation of mast cells, which was observed between 4 and 24 hours after challenge, reached a peak at 8 hours. Piecemeal degranulation was seen during the immediate phase reaction. The number of IL-6–positive mast cells was increased after 4 hours in both IgE-sensitized and unsensitized mice, but positive cells showed a greater increase in sensitized mice and reached a peak after 8 hours. With in situ hybridization experiments, mast cells were positive for IL-6 messenger RNA at 6 hours after challenge. Conclusion: These findings indicate that anaphylactic degranulation of mast cells and the expression of IL-6 mRNA within 4 hours after antigen challenge are important for the onset of the late-phase allergic cutaneous reaction in mice. (J Allergy Clin Immunol 2000;106:S91-8.)" @default.
- W2085103671 created "2016-06-24" @default.
- W2085103671 creator A5016188185 @default.
- W2085103671 date "1984-03-01" @default.
- W2085103671 modified "2023-10-16" @default.
- W2085103671 title "Hypotheses on the contribution of late-phase allergic responses to the understanding and treatment of allergic diseases" @default.
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- W2085103671 doi "https://doi.org/10.1016/0091-6749(84)90401-9" @default.
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