FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085104417> ?p ?o ?g. }

• W2085104417 endingPage "5709" @default.
• W2085104417 startingPage "5700" @default.
• W2085104417 abstract "BACKGROUND: One-carbon metabolism plays a critical role in DNA methylation and DNA synthesis. Variants of genes involved in one-carbon metabolism may result in aberrant methylation and/or DNA synthesis inhibition, and ultimately modulate the initiation and progression of tumors. In this study, the authors hypothesized that polymorphisms in one-carbon metabolism-related genes may contribute to the prognosis of nonsmall cell lung cancer (NSCLC). METHODS: The authors screened 57 potentially functional single nucleotide polymorphisms (SNPs) from 11 candidate genes involved in one-carbon metabolism and genotyped them in a cohort of 568 NSCLC patients by using Illumina Golden Gate platform. The Kaplan-Meier method with log-rank test and Cox proportional hazards model were used for survival analyses. RESULTS: Variant alleles were significantly associated with favorable survivals of NSCLC for MTR rs3768160 A>G (allelic hazards ratio [HR], 0.78; 95% confidence interval [CI], 0.62-0.98), MTRR rs2966952 G>A (allelic HR, 0.84; 95% CI, 0.71-0.99) and DHFR rs1650697 G>A (allelic HR, 0.83; 95% CI, 0.70-0.99) and with unfavorable prognosis for MTHFD1 rs1950902 G>A with borderline significance (allelic HR, 1.18; 95% CI, 0.99-1.40). In addition, the combined genotypes of these four SNPs showed a locus-dosage effect on NSCLC survival (Ptrend = 6.9 × 10−5). In the final multivariate Cox regression model, combined genotypes based on 3 categories may be an independent prognostic factor for NSCLC with adjusted trend HR of 0.78 (95% CI, 0.66-0.92). CONCLUSION: Genetic variants in one-carbon metabolism pathway may be candidate biomarkers for NSCLC prognosis. Cancer 2010. © 2010 American Cancer Society." @default.
• W2085104417 created "2016-06-24" @default.
• W2085104417 creator A5001453048 @default.
• W2085104417 creator A5005806536 @default.
• W2085104417 creator A5032100785 @default.
• W2085104417 creator A5038619577 @default.
• W2085104417 creator A5041809670 @default.
• W2085104417 creator A5046849313 @default.
• W2085104417 creator A5049678335 @default.
• W2085104417 creator A5050536898 @default.
• W2085104417 creator A5078204635 @default.
• W2085104417 creator A5084213516 @default.
• W2085104417 date "2010-08-24" @default.
• W2085104417 modified "2023-10-14" @default.
• W2085104417 title "Genetic variants in one-carbon metabolism-related genes contribute to NSCLC prognosis in a Chinese population" @default.
• W2085104417 cites W1604586810 @default.
• W2085104417 cites W1945361080 @default.
• W2085104417 cites W1980046365 @default.
• W2085104417 cites W1985825541 @default.
• W2085104417 cites W1990308195 @default.
• W2085104417 cites W1993777583 @default.
• W2085104417 cites W2001525363 @default.
• W2085104417 cites W2020830322 @default.
• W2085104417 cites W2026963278 @default.
• W2085104417 cites W2044170424 @default.
• W2085104417 cites W2044538917 @default.
• W2085104417 cites W2049439467 @default.
• W2085104417 cites W2057469776 @default.
• W2085104417 cites W2061712427 @default.
• W2085104417 cites W2065223314 @default.
• W2085104417 cites W2076115527 @default.
• W2085104417 cites W2084362641 @default.
• W2085104417 cites W2090480028 @default.
• W2085104417 cites W2102945991 @default.
• W2085104417 cites W2103953940 @default.
• W2085104417 cites W2106664438 @default.
• W2085104417 cites W2117312367 @default.
• W2085104417 cites W2141325183 @default.
• W2085104417 cites W2145186722 @default.
• W2085104417 doi "https://doi.org/10.1002/cncr.25301" @default.
• W2085104417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20737570" @default.
• W2085104417 hasPublicationYear "2010" @default.
• W2085104417 type Work @default.
• W2085104417 sameAs 2085104417 @default.
• W2085104417 citedByCount "14" @default.
• W2085104417 countsByYear W20851044172012 @default.
• W2085104417 countsByYear W20851044172013 @default.
• W2085104417 countsByYear W20851044172014 @default.
• W2085104417 countsByYear W20851044172015 @default.
• W2085104417 countsByYear W20851044172017 @default.
• W2085104417 countsByYear W20851044172018 @default.
• W2085104417 countsByYear W20851044172019 @default.
• W2085104417 countsByYear W20851044172020 @default.
• W2085104417 countsByYear W20851044172022 @default.
• W2085104417 crossrefType "journal-article" @default.
• W2085104417 hasAuthorship W2085104417A5001453048 @default.
• W2085104417 hasAuthorship W2085104417A5005806536 @default.
• W2085104417 hasAuthorship W2085104417A5032100785 @default.
• W2085104417 hasAuthorship W2085104417A5038619577 @default.
• W2085104417 hasAuthorship W2085104417A5041809670 @default.
• W2085104417 hasAuthorship W2085104417A5046849313 @default.
• W2085104417 hasAuthorship W2085104417A5049678335 @default.
• W2085104417 hasAuthorship W2085104417A5050536898 @default.
• W2085104417 hasAuthorship W2085104417A5078204635 @default.
• W2085104417 hasAuthorship W2085104417A5084213516 @default.
• W2085104417 hasBestOaLocation W20851044171 @default.
• W2085104417 hasConcept C104317684 @default.
• W2085104417 hasConcept C126322002 @default.
• W2085104417 hasConcept C135763542 @default.
• W2085104417 hasConcept C143998085 @default.
• W2085104417 hasConcept C150194340 @default.
• W2085104417 hasConcept C153209595 @default.
• W2085104417 hasConcept C180754005 @default.
• W2085104417 hasConcept C190727270 @default.
• W2085104417 hasConcept C207103383 @default.
• W2085104417 hasConcept C2776256026 @default.
• W2085104417 hasConcept C2778087339 @default.
• W2085104417 hasConcept C43563269 @default.
• W2085104417 hasConcept C44249647 @default.
• W2085104417 hasConcept C50382708 @default.
• W2085104417 hasConcept C54355233 @default.
• W2085104417 hasConcept C71924100 @default.
• W2085104417 hasConcept C84597430 @default.
• W2085104417 hasConcept C86803240 @default.
• W2085104417 hasConceptScore W2085104417C104317684 @default.
• W2085104417 hasConceptScore W2085104417C126322002 @default.
• W2085104417 hasConceptScore W2085104417C135763542 @default.
• W2085104417 hasConceptScore W2085104417C143998085 @default.
• W2085104417 hasConceptScore W2085104417C150194340 @default.
• W2085104417 hasConceptScore W2085104417C153209595 @default.
• W2085104417 hasConceptScore W2085104417C180754005 @default.
• W2085104417 hasConceptScore W2085104417C190727270 @default.
• W2085104417 hasConceptScore W2085104417C207103383 @default.
• W2085104417 hasConceptScore W2085104417C2776256026 @default.
• W2085104417 hasConceptScore W2085104417C2778087339 @default.
• W2085104417 hasConceptScore W2085104417C43563269 @default.
• W2085104417 hasConceptScore W2085104417C44249647 @default.
• W2085104417 hasConceptScore W2085104417C50382708 @default.

• next