FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085114646> ?p ?o ?g. }

• W2085114646 endingPage "121" @default.
• W2085114646 startingPage "113" @default.
• W2085114646 abstract "The extract of Hypericum perforatum (St. John's wort, SJW) and its component hyperforin (HPF) were previously shown to inhibit cytokine-induced activation of signal transducer and activator of transcription-1 and nuclear factor κB and prevent apoptosis in a cultured β-cell line. Objective of this study was to assess the protection exerted by SJW and HPF on isolated rat and human islets exposed to cytokines in vitro. Functional, ultrastructural, biomolecular and cell death evaluation studies were performed. In both rat and human islets, SJW and HPF counteracted cytokine-induced functional impairment and down-regulated mRNA expression of pro-inflammatory target genes, such as iNOS, CXCL9, CXCL10, COX2. Cytokine-induced NO production from cultured islets, evaluated by nitrites measurement in the medium, was significantly reduced in the presence of the vegetal compounds. Noteworthy, the increase in apoptosis and necrosis following 48-h exposure to cytokines was fully prevented by SJW and partially by HPF. Ultrastructural morphometric analysis in human islets exposed to cytokines for 20 h showed that SJW or HPF avoided early β-cell damage (e.g., mitochondrial alterations and loss of insulin granules). In conclusion, SJW compounds protect rat and human islets against cytokine effects by counteracting key mechanisms of cytokine-mediated β-cell injury and represent promising pharmacological tools for prevention or limitation of β-cell dysfunction and loss in type 1 diabetes." @default.
• W2085114646 created "2016-06-24" @default.
• W2085114646 creator A5000550995 @default.
• W2085114646 creator A5004928192 @default.
• W2085114646 creator A5018890288 @default.
• W2085114646 creator A5035837693 @default.
• W2085114646 creator A5038355565 @default.
• W2085114646 creator A5039540619 @default.
• W2085114646 creator A5061597548 @default.
• W2085114646 creator A5064940370 @default.
• W2085114646 creator A5079651217 @default.
• W2085114646 creator A5087771312 @default.
• W2085114646 creator A5089713869 @default.
• W2085114646 date "2013-10-12" @default.
• W2085114646 modified "2023-10-14" @default.
• W2085114646 title "St. John’s wort extract and hyperforin protect rat and human pancreatic islets against cytokine toxicity" @default.
• W2085114646 cites W1598741049 @default.
• W2085114646 cites W1839288048 @default.
• W2085114646 cites W1966346152 @default.
• W2085114646 cites W1973135736 @default.
• W2085114646 cites W1977934529 @default.
• W2085114646 cites W2005164022 @default.
• W2085114646 cites W2011007912 @default.
• W2085114646 cites W2018866981 @default.
• W2085114646 cites W2019698047 @default.
• W2085114646 cites W2019787595 @default.
• W2085114646 cites W2023590295 @default.
• W2085114646 cites W2026152957 @default.
• W2085114646 cites W2035264033 @default.
• W2085114646 cites W2043188148 @default.
• W2085114646 cites W2057460243 @default.
• W2085114646 cites W2062198431 @default.
• W2085114646 cites W2065991922 @default.
• W2085114646 cites W2069819213 @default.
• W2085114646 cites W2071878999 @default.
• W2085114646 cites W2072611681 @default.
• W2085114646 cites W2076458350 @default.
• W2085114646 cites W2089934054 @default.
• W2085114646 cites W2093210281 @default.
• W2085114646 cites W2095372191 @default.
• W2085114646 cites W2099035008 @default.
• W2085114646 cites W2101268659 @default.
• W2085114646 cites W2103710297 @default.
• W2085114646 cites W2110330548 @default.
• W2085114646 cites W2112371420 @default.
• W2085114646 cites W2128737073 @default.
• W2085114646 cites W2130764919 @default.
• W2085114646 cites W2131322950 @default.
• W2085114646 cites W2131936676 @default.
• W2085114646 cites W2138534354 @default.
• W2085114646 cites W2157476554 @default.
• W2085114646 cites W2322090980 @default.
• W2085114646 cites W4242514389 @default.
• W2085114646 doi "https://doi.org/10.1007/s00592-013-0518-2" @default.
• W2085114646 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3923109" @default.
• W2085114646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24121871" @default.
• W2085114646 hasPublicationYear "2013" @default.
• W2085114646 type Work @default.
• W2085114646 sameAs 2085114646 @default.
• W2085114646 citedByCount "23" @default.
• W2085114646 countsByYear W20851146462015 @default.
• W2085114646 countsByYear W20851146462016 @default.
• W2085114646 countsByYear W20851146462017 @default.
• W2085114646 countsByYear W20851146462018 @default.
• W2085114646 countsByYear W20851146462019 @default.
• W2085114646 countsByYear W20851146462020 @default.
• W2085114646 countsByYear W20851146462021 @default.
• W2085114646 countsByYear W20851146462022 @default.
• W2085114646 countsByYear W20851146462023 @default.
• W2085114646 crossrefType "journal-article" @default.
• W2085114646 hasAuthorship W2085114646A5000550995 @default.
• W2085114646 hasAuthorship W2085114646A5004928192 @default.
• W2085114646 hasAuthorship W2085114646A5018890288 @default.
• W2085114646 hasAuthorship W2085114646A5035837693 @default.
• W2085114646 hasAuthorship W2085114646A5038355565 @default.
• W2085114646 hasAuthorship W2085114646A5039540619 @default.
• W2085114646 hasAuthorship W2085114646A5061597548 @default.
• W2085114646 hasAuthorship W2085114646A5064940370 @default.
• W2085114646 hasAuthorship W2085114646A5079651217 @default.
• W2085114646 hasAuthorship W2085114646A5087771312 @default.
• W2085114646 hasAuthorship W2085114646A5089713869 @default.
• W2085114646 hasBestOaLocation W20851146461 @default.
• W2085114646 hasConcept C134018914 @default.
• W2085114646 hasConcept C164027704 @default.
• W2085114646 hasConcept C165220095 @default.
• W2085114646 hasConcept C17991360 @default.
• W2085114646 hasConcept C185592680 @default.
• W2085114646 hasConcept C190283241 @default.
• W2085114646 hasConcept C203014093 @default.
• W2085114646 hasConcept C2776651039 @default.
• W2085114646 hasConcept C2776914184 @default.
• W2085114646 hasConcept C2778350159 @default.
• W2085114646 hasConcept C2778690821 @default.
• W2085114646 hasConcept C2779855799 @default.
• W2085114646 hasConcept C31573885 @default.
• W2085114646 hasConcept C55493867 @default.
• W2085114646 hasConcept C555293320 @default.
• W2085114646 hasConcept C71924100 @default.

• next