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• W2085114962 startingPage "681" @default.
• W2085114962 abstract "Of the ∼400 known human proteases, ∼14% are under investigation as drug targets. Although the total is certain to rise during the finishing phase of the human genome project, the initial annotation of the ∼30,000 human proteome set includes ∼500 proteases. Bioinformatic analysis can now be performed on complete human protease families and will soon include comparisons with mice and fish. New sequences will require evaluation of their function in normal physiology and human disease. By revealing details such as splice variants and population polymorphisms, genomic sequence information will have a central role in the validation of protease drug targets." @default.
• W2085114962 created "2016-06-24" @default.
• W2085114962 creator A5039959378 @default.
• W2085114962 date "2001-07-01" @default.
• W2085114962 modified "2023-09-25" @default.
• W2085114962 title "A genomic perspective on human proteases as drug targets" @default.
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• W2085114962 doi "https://doi.org/10.1016/s1359-6446(01)01793-7" @default.
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