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• W2085116513 abstract "ObjectiveGlycemic derangements are associated with adverse neonatal outcomes; however, birth glucose levels have never been investigated as a predictor of neurological outcomes. We hypothesized that suboptimal peripheral birth glucose levels would be predictive of periventricular white matter injury (PWMI) in premature infants.Study DesignWe conducted a 2:1 age matched case-control study comparing premature infants with PWMI at 7 days of life to controls with normal head ultrasounds. Glucose levels were obtained via heel sticks prior to any postnatal intervention. Cases and controls were compared in regards to demographics, maternal medical conditions and prenatal complications. Standard statistics including T-tests, chi square and logistic regression were performed using STATA version 11 (Chicago, IL). Power calculations were performed. Sensitivity and specificity were evaluated.ResultsForty seven infants were identified, including 16 with ultrasound evidence of PWMI and 31 age-matched controls. The neonates with PVL had a median gestational age (GA) of 26.9 weeks (SD 3.7), mean birthweight of 1121.3 grams (SD 607.7), and mean cord pH of 7.24 (SD 0.18). The age-matched controls had a median GA of 26.9 weeks (SD 3.5), mean birthweight of 1112.5 grams (SD 477.3) and mean cord pH of 7.26 (SD 0.14). Logisitic regression revealed an odds ratio 0.24 (95% CI 0.063-0.902) for abnormal ultrasound findings associated with glucose< 85 mg/dL (significant even after controlling for confounders), with sensitivity of 50% and specificity of 73%.ConclusionPeripheral glucose below 85 mg/dL appeared to be protective against PWMI, possibly reflecting the importance of glucose autoregulation in preterm infants. Peripheral birth glucose may prove to be an additional risk stratification tool for preterm infants. ObjectiveGlycemic derangements are associated with adverse neonatal outcomes; however, birth glucose levels have never been investigated as a predictor of neurological outcomes. We hypothesized that suboptimal peripheral birth glucose levels would be predictive of periventricular white matter injury (PWMI) in premature infants. Glycemic derangements are associated with adverse neonatal outcomes; however, birth glucose levels have never been investigated as a predictor of neurological outcomes. We hypothesized that suboptimal peripheral birth glucose levels would be predictive of periventricular white matter injury (PWMI) in premature infants. Study DesignWe conducted a 2:1 age matched case-control study comparing premature infants with PWMI at 7 days of life to controls with normal head ultrasounds. Glucose levels were obtained via heel sticks prior to any postnatal intervention. Cases and controls were compared in regards to demographics, maternal medical conditions and prenatal complications. Standard statistics including T-tests, chi square and logistic regression were performed using STATA version 11 (Chicago, IL). Power calculations were performed. Sensitivity and specificity were evaluated. We conducted a 2:1 age matched case-control study comparing premature infants with PWMI at 7 days of life to controls with normal head ultrasounds. Glucose levels were obtained via heel sticks prior to any postnatal intervention. Cases and controls were compared in regards to demographics, maternal medical conditions and prenatal complications. Standard statistics including T-tests, chi square and logistic regression were performed using STATA version 11 (Chicago, IL). Power calculations were performed. Sensitivity and specificity were evaluated. ResultsForty seven infants were identified, including 16 with ultrasound evidence of PWMI and 31 age-matched controls. The neonates with PVL had a median gestational age (GA) of 26.9 weeks (SD 3.7), mean birthweight of 1121.3 grams (SD 607.7), and mean cord pH of 7.24 (SD 0.18). The age-matched controls had a median GA of 26.9 weeks (SD 3.5), mean birthweight of 1112.5 grams (SD 477.3) and mean cord pH of 7.26 (SD 0.14). Logisitic regression revealed an odds ratio 0.24 (95% CI 0.063-0.902) for abnormal ultrasound findings associated with glucose< 85 mg/dL (significant even after controlling for confounders), with sensitivity of 50% and specificity of 73%. Forty seven infants were identified, including 16 with ultrasound evidence of PWMI and 31 age-matched controls. The neonates with PVL had a median gestational age (GA) of 26.9 weeks (SD 3.7), mean birthweight of 1121.3 grams (SD 607.7), and mean cord pH of 7.24 (SD 0.18). The age-matched controls had a median GA of 26.9 weeks (SD 3.5), mean birthweight of 1112.5 grams (SD 477.3) and mean cord pH of 7.26 (SD 0.14). Logisitic regression revealed an odds ratio 0.24 (95% CI 0.063-0.902) for abnormal ultrasound findings associated with glucose< 85 mg/dL (significant even after controlling for confounders), with sensitivity of 50% and specificity of 73%. ConclusionPeripheral glucose below 85 mg/dL appeared to be protective against PWMI, possibly reflecting the importance of glucose autoregulation in preterm infants. Peripheral birth glucose may prove to be an additional risk stratification tool for preterm infants. Peripheral glucose below 85 mg/dL appeared to be protective against PWMI, possibly reflecting the importance of glucose autoregulation in preterm infants. Peripheral birth glucose may prove to be an additional risk stratification tool for preterm infants." @default.
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• W2085116513 title "525: Peripheral glucose levels at birth and diagnosis of periventricular white matter injury in premature neonates" @default.
• W2085116513 doi "https://doi.org/10.1016/j.ajog.2012.10.691" @default.
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