Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085118833> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2085118833 endingPage "1021" @default.
- W2085118833 startingPage "1017" @default.
- W2085118833 abstract "A new oral agent, 5-[4-[2-(5-ethyl-12-pyridyl)ethoxy]-benzyl]-2,4-thiazolidinedione, or pioglitazone, has been developed for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). We examined its effectiveness in high-fat-fed rats resistant to insulin. Administration of the agent (10 mg · kg−1 · d−1) for 2 weeks resulted in decreases in hyperlipidemia and hyperinsulinemia, indicating that insulin sensitivity had increased in vivo in high-fat-fed rats. To clarify the mechanism of the drug, we examined insulin binding and kinase activity of insulin receptors from muscles of both untreated and treated high-fat-fed rats. Pioglitazone treatment did not change insulin binding in high-fat-fed rats, but increased insulin-stimulated autophosphorylation of insulin receptors to the level of control animals. Kinase activity toward an exogenous substrate, poly Glu4-Tyr1, in pioglitazone-treated high-fat-fed rats was also increased to the level of control animals. These results suggest that pioglitazone increases insulin sensitivity by activating tyrosine kinase activity of receptors in high-fat-fed rats, and this drug appears to be a useful one with a new mode of action for the treatment of NIDDM with insulin resistance." @default.
- W2085118833 created "2016-06-24" @default.
- W2085118833 creator A5048136133 @default.
- W2085118833 creator A5088134645 @default.
- W2085118833 date "1993-08-01" @default.
- W2085118833 modified "2023-09-29" @default.
- W2085118833 title "Effect of pioglitazone on insulin receptors of skeletal muscles from high-fat-fed rats" @default.
- W2085118833 cites W1536886415 @default.
- W2085118833 cites W1563608944 @default.
- W2085118833 cites W1969478165 @default.
- W2085118833 cites W1980136960 @default.
- W2085118833 cites W1984275236 @default.
- W2085118833 cites W1984513597 @default.
- W2085118833 cites W2003420643 @default.
- W2085118833 cites W2022343395 @default.
- W2085118833 cites W2033125833 @default.
- W2085118833 cites W2053685370 @default.
- W2085118833 cites W2064587690 @default.
- W2085118833 cites W2066129135 @default.
- W2085118833 cites W2069069354 @default.
- W2085118833 cites W4232034232 @default.
- W2085118833 cites W4240093778 @default.
- W2085118833 cites W4241368298 @default.
- W2085118833 cites W4244480613 @default.
- W2085118833 cites W4249615199 @default.
- W2085118833 cites W63640904 @default.
- W2085118833 doi "https://doi.org/10.1016/0026-0495(93)90016-h" @default.
- W2085118833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8345805" @default.
- W2085118833 hasPublicationYear "1993" @default.
- W2085118833 type Work @default.
- W2085118833 sameAs 2085118833 @default.
- W2085118833 citedByCount "53" @default.
- W2085118833 countsByYear W20851188332012 @default.
- W2085118833 countsByYear W20851188332013 @default.
- W2085118833 countsByYear W20851188332014 @default.
- W2085118833 countsByYear W20851188332015 @default.
- W2085118833 countsByYear W20851188332016 @default.
- W2085118833 countsByYear W20851188332019 @default.
- W2085118833 countsByYear W20851188332023 @default.
- W2085118833 crossrefType "journal-article" @default.
- W2085118833 hasAuthorship W2085118833A5048136133 @default.
- W2085118833 hasAuthorship W2085118833A5088134645 @default.
- W2085118833 hasConcept C112446052 @default.
- W2085118833 hasConcept C126322002 @default.
- W2085118833 hasConcept C134018914 @default.
- W2085118833 hasConcept C170493617 @default.
- W2085118833 hasConcept C2776923340 @default.
- W2085118833 hasConcept C2777180221 @default.
- W2085118833 hasConcept C2777391703 @default.
- W2085118833 hasConcept C2778384471 @default.
- W2085118833 hasConcept C2779306644 @default.
- W2085118833 hasConcept C2780988686 @default.
- W2085118833 hasConcept C555293320 @default.
- W2085118833 hasConcept C71924100 @default.
- W2085118833 hasConceptScore W2085118833C112446052 @default.
- W2085118833 hasConceptScore W2085118833C126322002 @default.
- W2085118833 hasConceptScore W2085118833C134018914 @default.
- W2085118833 hasConceptScore W2085118833C170493617 @default.
- W2085118833 hasConceptScore W2085118833C2776923340 @default.
- W2085118833 hasConceptScore W2085118833C2777180221 @default.
- W2085118833 hasConceptScore W2085118833C2777391703 @default.
- W2085118833 hasConceptScore W2085118833C2778384471 @default.
- W2085118833 hasConceptScore W2085118833C2779306644 @default.
- W2085118833 hasConceptScore W2085118833C2780988686 @default.
- W2085118833 hasConceptScore W2085118833C555293320 @default.
- W2085118833 hasConceptScore W2085118833C71924100 @default.
- W2085118833 hasIssue "8" @default.
- W2085118833 hasLocation W20851188331 @default.
- W2085118833 hasLocation W20851188332 @default.
- W2085118833 hasOpenAccess W2085118833 @default.
- W2085118833 hasPrimaryLocation W20851188331 @default.
- W2085118833 hasRelatedWork W2010140898 @default.
- W2085118833 hasRelatedWork W2028395411 @default.
- W2085118833 hasRelatedWork W2058152093 @default.
- W2085118833 hasRelatedWork W2082140668 @default.
- W2085118833 hasRelatedWork W2138266804 @default.
- W2085118833 hasRelatedWork W2416996015 @default.
- W2085118833 hasRelatedWork W2886303208 @default.
- W2085118833 hasRelatedWork W4234612679 @default.
- W2085118833 hasRelatedWork W4255499926 @default.
- W2085118833 hasRelatedWork W8919293 @default.
- W2085118833 hasVolume "42" @default.
- W2085118833 isParatext "false" @default.
- W2085118833 isRetracted "false" @default.
- W2085118833 magId "2085118833" @default.
- W2085118833 workType "article" @default.