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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085122016> ?p ?o ?g. }

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• W2085122016 abstract "A series of novel anilino 5-azaimidazoquinoxaline analogues possessing potent in vitro activity against p56Lck and T cell proliferation have been discovered. Subsequent SAR studies led to the identification of compound 4 (BMS-279700) as an orally active lead candidate that blocks the production of proinflammatory cytokines (IL-2 and TNFα) in vivo. In addition, an expanded set of imidazoquinoxalines provided several descriptive QSAR models highlighting the influence of significant steric and electronic features. The H-bonding (Met319) contribution to observed binding affinities within a tightly congeneric series was found to be significant." @default.
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• W2085122016 date "2004-07-27" @default.
• W2085122016 modified "2023-10-03" @default.
• W2085122016 title "Imidazoquinoxaline Src-Family Kinase p56^Lck Inhibitors: SAR, QSAR, and the Discovery of (<i>S</i>)-<i>N</i>-(2-Chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-<i>a</i>]pyrido[3,2-<i>e</i>]pyrazin-6-amine (BMS-279700) as a Potent and Orally Active Inhibitor with Excellent in Vivo Antiinflammatory Activity" @default.
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• W2085122016 doi "https://doi.org/10.1021/jm030217e" @default.
• W2085122016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15317463" @default.
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