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- W2085123777 endingPage "12745" @default.
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- W2085123777 abstract "Significance Biological fitness is dependent on the accurate flow of genetic information from DNA to mRNA to protein. Breakdown in ribosome translational fidelity is detrimental because of its central role in the production of proteins. Altering the 3-base genetic code usually results in the expression of aberrant or nonsense proteins that are degraded. Here, we describe molecular snapshots of the ribosome in the process of decoding a 4-base codon by a frameshift suppressor tRNA that results in a +1-nt shift of the mRNA reading frame. Conformational dynamics of the anticodon stem loop seem to drive remodeling of the tRNA–mRNA interaction to promote the +1 movement, which we predict occurs after accommodation of the tRNA onto the ribosome." @default.
- W2085123777 created "2016-06-24" @default.
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- W2085123777 date "2014-08-15" @default.
- W2085123777 modified "2023-10-16" @default.
- W2085123777 title "Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops" @default.
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- W2085123777 doi "https://doi.org/10.1073/pnas.1409436111" @default.
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