FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085127625> ?p ?o ?g. }

• W2085127625 endingPage "e136" @default.
• W2085127625 startingPage "e136" @default.
• W2085127625 abstract "The activation and regulation of target genes by the tumour-suppressor p53 dictates the fate of a cell, with cell cycle arrest or apoptosis being two distinct outcomes. PERP (p53 apoptosis effector related to PMP-22), a p53 transcriptional target, is induced specifically during apoptosis but not cell cycle arrest. Downregulation of PERP is associated with the aggressive, monosomy 3-type of uveal melanoma (UM), the most common primary intraocular tumour in adults, and increased PERP expression has a pro-apoptotic effect in UM cells. Here, we identify a novel effect of PERP expression, as elevated PERP protein positively influences active levels of its own transcriptional regulator, p53. Using fluorescent fusion proteins of PERP, p53 and MDM2, we demonstrate in single living UM cells that PERP expression significantly enhances p53 activity and its nuclear localization, increases p53-dependent transcription (including that of MDM2) while allowing oscillatory nucleo-cytoplasmic shuttling of p53/MDM2 complexes. Phosphorylation of p53 serine residues that interfere with the interaction between p53 and its negative regulator MDM2 and enhance pro-apoptotic gene transcription also occurs subsequent to PERP expression. These results implicate a role for PERP in amplifying functional p53 levels that promote p53-dependent apoptosis, and reveal a potential target for exploitation in enhancing p53 activity." @default.
• W2085127625 created "2016-06-24" @default.
• W2085127625 creator A5043672470 @default.
• W2085127625 creator A5060836920 @default.
• W2085127625 creator A5087653688 @default.
• W2085127625 creator A5088526885 @default.
• W2085127625 creator A5089379775 @default.
• W2085127625 date "2011-03-31" @default.
• W2085127625 modified "2023-10-06" @default.
• W2085127625 title "PERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells" @default.
• W2085127625 cites W1650797637 @default.
• W2085127625 cites W1937607074 @default.
• W2085127625 cites W1964719993 @default.
• W2085127625 cites W1975644211 @default.
• W2085127625 cites W1978518304 @default.
• W2085127625 cites W1991494214 @default.
• W2085127625 cites W1995741673 @default.
• W2085127625 cites W2008887283 @default.
• W2085127625 cites W2009004396 @default.
• W2085127625 cites W2024604828 @default.
• W2085127625 cites W2027547124 @default.
• W2085127625 cites W2040429923 @default.
• W2085127625 cites W2041786888 @default.
• W2085127625 cites W2050981751 @default.
• W2085127625 cites W2054311839 @default.
• W2085127625 cites W2056530510 @default.
• W2085127625 cites W2060584880 @default.
• W2085127625 cites W2060618478 @default.
• W2085127625 cites W2060680724 @default.
• W2085127625 cites W2063822655 @default.
• W2085127625 cites W2078361436 @default.
• W2085127625 cites W2079706088 @default.
• W2085127625 cites W2082979850 @default.
• W2085127625 cites W2095424453 @default.
• W2085127625 cites W2095916340 @default.
• W2085127625 cites W2097651998 @default.
• W2085127625 cites W2109183374 @default.
• W2085127625 cites W2112480698 @default.
• W2085127625 cites W2123017967 @default.
• W2085127625 cites W2123744235 @default.
• W2085127625 cites W2138255873 @default.
• W2085127625 cites W2142826829 @default.
• W2085127625 cites W2155363874 @default.
• W2085127625 cites W2155640249 @default.
• W2085127625 cites W2160340008 @default.
• W2085127625 cites W2166213130 @default.
• W2085127625 cites W2170759803 @default.
• W2085127625 doi "https://doi.org/10.1038/cddis.2011.19" @default.
• W2085127625 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3101815" @default.
• W2085127625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21451571" @default.
• W2085127625 hasPublicationYear "2011" @default.
• W2085127625 type Work @default.
• W2085127625 sameAs 2085127625 @default.
• W2085127625 citedByCount "32" @default.
• W2085127625 countsByYear W20851276252012 @default.
• W2085127625 countsByYear W20851276252013 @default.
• W2085127625 countsByYear W20851276252014 @default.
• W2085127625 countsByYear W20851276252015 @default.
• W2085127625 countsByYear W20851276252016 @default.
• W2085127625 countsByYear W20851276252017 @default.
• W2085127625 countsByYear W20851276252018 @default.
• W2085127625 countsByYear W20851276252019 @default.
• W2085127625 countsByYear W20851276252020 @default.
• W2085127625 countsByYear W20851276252021 @default.
• W2085127625 countsByYear W20851276252022 @default.
• W2085127625 countsByYear W20851276252023 @default.
• W2085127625 crossrefType "journal-article" @default.
• W2085127625 hasAuthorship W2085127625A5043672470 @default.
• W2085127625 hasAuthorship W2085127625A5060836920 @default.
• W2085127625 hasAuthorship W2085127625A5087653688 @default.
• W2085127625 hasAuthorship W2085127625A5088526885 @default.
• W2085127625 hasAuthorship W2085127625A5089379775 @default.
• W2085127625 hasBestOaLocation W20851276251 @default.
• W2085127625 hasConcept C104317684 @default.
• W2085127625 hasConcept C105696609 @default.
• W2085127625 hasConcept C127561419 @default.
• W2085127625 hasConcept C190283241 @default.
• W2085127625 hasConcept C2776192174 @default.
• W2085127625 hasConcept C29537977 @default.
• W2085127625 hasConcept C502942594 @default.
• W2085127625 hasConcept C51785407 @default.
• W2085127625 hasConcept C54355233 @default.
• W2085127625 hasConcept C6929976 @default.
• W2085127625 hasConcept C86339819 @default.
• W2085127625 hasConcept C86803240 @default.
• W2085127625 hasConcept C95444343 @default.
• W2085127625 hasConceptScore W2085127625C104317684 @default.
• W2085127625 hasConceptScore W2085127625C105696609 @default.
• W2085127625 hasConceptScore W2085127625C127561419 @default.
• W2085127625 hasConceptScore W2085127625C190283241 @default.
• W2085127625 hasConceptScore W2085127625C2776192174 @default.
• W2085127625 hasConceptScore W2085127625C29537977 @default.
• W2085127625 hasConceptScore W2085127625C502942594 @default.
• W2085127625 hasConceptScore W2085127625C51785407 @default.
• W2085127625 hasConceptScore W2085127625C54355233 @default.
• W2085127625 hasConceptScore W2085127625C6929976 @default.
• W2085127625 hasConceptScore W2085127625C86339819 @default.
• W2085127625 hasConceptScore W2085127625C86803240 @default.

• next