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• W2085127795 abstract "The mean concentration of cholesterol in the body of the normal male rat fed a balanced laboratory chow was 1.72 mg./Gm. body weight. Hyperthyroidism produced by the daily injection of either L-thyroxine or D-thyroxine resulted in an increase in concentration, largely from increased cholesterol concentration of the skin. Thyroidectomy had no effect on total body cholesterol. The addition of cholesterol to the diet caused an increase in cholesterol of the euthyroid rat to 2.25 mg./Gm. body weight, the greater part of the increase being in the liver. In the cholesterol-fed rat hyperthyroidism resulted in a reduced total body cholesterol, due almost entirely to a lower concentration in the liver. Thyroidectomy accentuated the accumulation of cholesterol in the liver of the cholesterol-fed rat. Hyperthyroidism resulted in hypertrophy of heart, kidneys, liver, gastrointestinal tract, lungs and spleen, relative to body weight; hypothyroidism caused a decrease in weight of these organs. These effects of the thyroid state on organ weights were not significantly influenced by the addition of cholesterol to the diet. The mean concentration of cholesterol in the body of the normal male rat fed a balanced laboratory chow was 1.72 mg./Gm. body weight. Hyperthyroidism produced by the daily injection of either L-thyroxine or D-thyroxine resulted in an increase in concentration, largely from increased cholesterol concentration of the skin. Thyroidectomy had no effect on total body cholesterol. The addition of cholesterol to the diet caused an increase in cholesterol of the euthyroid rat to 2.25 mg./Gm. body weight, the greater part of the increase being in the liver. In the cholesterol-fed rat hyperthyroidism resulted in a reduced total body cholesterol, due almost entirely to a lower concentration in the liver. Thyroidectomy accentuated the accumulation of cholesterol in the liver of the cholesterol-fed rat. Hyperthyroidism resulted in hypertrophy of heart, kidneys, liver, gastrointestinal tract, lungs and spleen, relative to body weight; hypothyroidism caused a decrease in weight of these organs. These effects of the thyroid state on organ weights were not significantly influenced by the addition of cholesterol to the diet." @default.
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• W2085127795 date "1964-01-01" @default.
• W2085127795 modified "2023-09-27" @default.
• W2085127795 title "Effects of L- and D-thyroxine and of thyroidectomy on tissue weights and cholesterol content of the rat" @default.
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• W2085127795 doi "https://doi.org/10.1016/s0026-0495(64)80002-0" @default.
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