Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085127906> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2085127906 endingPage "A288" @default.
- W2085127906 startingPage "A288" @default.
- W2085127906 abstract "5-Hydroxytryptamine is a mediator in cholera toxin-induced hypersecretion in the small intestine. Our hypothesis is that the hypersecretion induced by 5-hydroxytryptamine in the small intestine decreases with increasing age and in an aboral direction in the small intestine. In vivo, measuring accumulated fluid in ligated loops, the apparent maximal efficacy of the 5-hydroxytryptamine-induced jejunal secretion in pig neonates was 4.8±1.1 mg·mg−1 dry loop·45 min−1. The apparent maximal efficacy decreased by 23% and 63% in young and adult pigs, respectively, compared with neonates. In vitro, measuring changes in short-circuit current in Ussing chambers, the apparent maximal efficacy was 66.7±4.8 μA·cm−2 in neonates and was reduced by 30% and 57% in young and adult pigs, respectively. Young pigs were used in the segmental study. The apparent maximal efficacy in vivo was 3.7±0.5 mg·mg−1 dry loop and decreased by 22% and 56% in the mid and distal small intestine, respectively. By contrast, in vitro the apparent maximal efficacy was elevated by 56% to 72.0±5.0 μA·cm−2 in the distal compared with the proximal part. In conclusion, the secretory response to 5-hydroxytryptamine in pig small intestine decreases with increasing age and in the aboral direction according to in vivo results. We suggest that the decrease in sensitivity to 5-hydroxytryptamine can explain a part of the reduced secretory response to cholera toxin with age and in the aboral direction of the small intestine." @default.
- W2085127906 created "2016-06-24" @default.
- W2085127906 creator A5016182098 @default.
- W2085127906 creator A5034777344 @default.
- W2085127906 creator A5039348201 @default.
- W2085127906 creator A5063990228 @default.
- W2085127906 date "1995-04-01" @default.
- W2085127906 modified "2023-09-26" @default.
- W2085127906 title "Age and segmental differences in 5-hydroxytryptamine-induced hypersecretion in pig small intestine" @default.
- W2085127906 cites W1208895987 @default.
- W2085127906 cites W1502683081 @default.
- W2085127906 cites W1620485062 @default.
- W2085127906 cites W1635782272 @default.
- W2085127906 cites W1823897678 @default.
- W2085127906 cites W1853525790 @default.
- W2085127906 cites W1871122671 @default.
- W2085127906 cites W1928775315 @default.
- W2085127906 cites W1987745937 @default.
- W2085127906 cites W1987998655 @default.
- W2085127906 cites W1998904527 @default.
- W2085127906 cites W2010009087 @default.
- W2085127906 cites W2017982279 @default.
- W2085127906 cites W2021201390 @default.
- W2085127906 cites W2026333972 @default.
- W2085127906 cites W2030743800 @default.
- W2085127906 cites W2036758747 @default.
- W2085127906 cites W2046183169 @default.
- W2085127906 cites W2049163192 @default.
- W2085127906 cites W2057212992 @default.
- W2085127906 cites W2060320478 @default.
- W2085127906 cites W2077293060 @default.
- W2085127906 cites W2078528638 @default.
- W2085127906 cites W2079636877 @default.
- W2085127906 cites W2085979316 @default.
- W2085127906 cites W2088479618 @default.
- W2085127906 cites W2089549982 @default.
- W2085127906 cites W2098149629 @default.
- W2085127906 cites W2104942013 @default.
- W2085127906 cites W2105136745 @default.
- W2085127906 cites W2153337095 @default.
- W2085127906 cites W2161371761 @default.
- W2085127906 cites W2170727937 @default.
- W2085127906 cites W2172824302 @default.
- W2085127906 cites W2173072461 @default.
- W2085127906 cites W2199664244 @default.
- W2085127906 cites W2321078197 @default.
- W2085127906 cites W2409282454 @default.
- W2085127906 cites W2423928808 @default.
- W2085127906 cites W2442565825 @default.
- W2085127906 cites W42839672 @default.
- W2085127906 doi "https://doi.org/10.1016/0016-5085(95)23812-3" @default.
- W2085127906 hasPublicationYear "1995" @default.
- W2085127906 type Work @default.
- W2085127906 sameAs 2085127906 @default.
- W2085127906 citedByCount "0" @default.
- W2085127906 crossrefType "journal-article" @default.
- W2085127906 hasAuthorship W2085127906A5016182098 @default.
- W2085127906 hasAuthorship W2085127906A5034777344 @default.
- W2085127906 hasAuthorship W2085127906A5039348201 @default.
- W2085127906 hasAuthorship W2085127906A5063990228 @default.
- W2085127906 hasConcept C126322002 @default.
- W2085127906 hasConcept C134018914 @default.
- W2085127906 hasConcept C2777882243 @default.
- W2085127906 hasConcept C71924100 @default.
- W2085127906 hasConcept C86803240 @default.
- W2085127906 hasConceptScore W2085127906C126322002 @default.
- W2085127906 hasConceptScore W2085127906C134018914 @default.
- W2085127906 hasConceptScore W2085127906C2777882243 @default.
- W2085127906 hasConceptScore W2085127906C71924100 @default.
- W2085127906 hasConceptScore W2085127906C86803240 @default.
- W2085127906 hasIssue "4" @default.
- W2085127906 hasLocation W20851279061 @default.
- W2085127906 hasOpenAccess W2085127906 @default.
- W2085127906 hasPrimaryLocation W20851279061 @default.
- W2085127906 hasRelatedWork W1965328949 @default.
- W2085127906 hasRelatedWork W1980781889 @default.
- W2085127906 hasRelatedWork W1990804418 @default.
- W2085127906 hasRelatedWork W1993764875 @default.
- W2085127906 hasRelatedWork W2067721066 @default.
- W2085127906 hasRelatedWork W2082860237 @default.
- W2085127906 hasRelatedWork W2106123096 @default.
- W2085127906 hasRelatedWork W2128769994 @default.
- W2085127906 hasRelatedWork W2130076355 @default.
- W2085127906 hasRelatedWork W2417190956 @default.
- W2085127906 hasVolume "108" @default.
- W2085127906 isParatext "false" @default.
- W2085127906 isRetracted "false" @default.
- W2085127906 magId "2085127906" @default.
- W2085127906 workType "article" @default.