Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085128212> ?p ?o ?g. }
- W2085128212 endingPage "120" @default.
- W2085128212 startingPage "115" @default.
- W2085128212 abstract "Quercetin is one of flavonoids with cyto-protective activities. It has been demonstrated that quercetin inhibits oxidative stress in some animal models and specific cells, but the particular mechanism is known a little. In the present study, we found that quercetin could decrease the expression of Krüppel-like factor 4 (KLF4) induced by hydrogen peroxide (H2O2) in human neuroblastoma SH-SY5Y cells, further increase the expression ratio of bcl-2 to bax, which were apoptotic-related target genes of KLF4, thus alleviate the apoptotic rate and caspase-3 enzyme activity of SH-5YSY cells; the overexpression or inhibition of KLF4 demonstrated the mediated role of KLF4 for the protective effect of quercetin on cell damage induced by H2O2. All results suggest a potential molecular mechanism of quercetin protecting against the oxidative damage, which may be applied in the treatment of oxidative related diseases, such as neurodegeneration diseases." @default.
- W2085128212 created "2016-06-24" @default.
- W2085128212 creator A5002229333 @default.
- W2085128212 creator A5046881277 @default.
- W2085128212 creator A5053654612 @default.
- W2085128212 creator A5056181501 @default.
- W2085128212 creator A5085474609 @default.
- W2085128212 date "2012-10-01" @default.
- W2085128212 modified "2023-10-17" @default.
- W2085128212 title "Quercetin protects neuroblastoma SH-SY5Y cells against oxidative stress by inhibiting expression of Krüppel-like factor 4" @default.
- W2085128212 cites W1926131165 @default.
- W2085128212 cites W1964227379 @default.
- W2085128212 cites W1968744284 @default.
- W2085128212 cites W1972355779 @default.
- W2085128212 cites W1975167769 @default.
- W2085128212 cites W1988009341 @default.
- W2085128212 cites W1988240468 @default.
- W2085128212 cites W2007649442 @default.
- W2085128212 cites W2017165365 @default.
- W2085128212 cites W2017186251 @default.
- W2085128212 cites W2028544092 @default.
- W2085128212 cites W2030602933 @default.
- W2085128212 cites W2030796291 @default.
- W2085128212 cites W2041986831 @default.
- W2085128212 cites W2066060929 @default.
- W2085128212 cites W2075746486 @default.
- W2085128212 cites W2076340493 @default.
- W2085128212 cites W2078166953 @default.
- W2085128212 cites W2089124259 @default.
- W2085128212 cites W2132826785 @default.
- W2085128212 cites W2148229098 @default.
- W2085128212 cites W2151912557 @default.
- W2085128212 cites W2153242177 @default.
- W2085128212 doi "https://doi.org/10.1016/j.neulet.2012.08.082" @default.
- W2085128212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22985515" @default.
- W2085128212 hasPublicationYear "2012" @default.
- W2085128212 type Work @default.
- W2085128212 sameAs 2085128212 @default.
- W2085128212 citedByCount "13" @default.
- W2085128212 countsByYear W20851282122013 @default.
- W2085128212 countsByYear W20851282122016 @default.
- W2085128212 countsByYear W20851282122017 @default.
- W2085128212 countsByYear W20851282122018 @default.
- W2085128212 countsByYear W20851282122019 @default.
- W2085128212 countsByYear W20851282122021 @default.
- W2085128212 countsByYear W20851282122022 @default.
- W2085128212 crossrefType "journal-article" @default.
- W2085128212 hasAuthorship W2085128212A5002229333 @default.
- W2085128212 hasAuthorship W2085128212A5046881277 @default.
- W2085128212 hasAuthorship W2085128212A5053654612 @default.
- W2085128212 hasAuthorship W2085128212A5056181501 @default.
- W2085128212 hasAuthorship W2085128212A5085474609 @default.
- W2085128212 hasConcept C104317684 @default.
- W2085128212 hasConcept C107459253 @default.
- W2085128212 hasConcept C145103041 @default.
- W2085128212 hasConcept C153911025 @default.
- W2085128212 hasConcept C185592680 @default.
- W2085128212 hasConcept C190283241 @default.
- W2085128212 hasConcept C2776151105 @default.
- W2085128212 hasConcept C2776715637 @default.
- W2085128212 hasConcept C2778004101 @default.
- W2085128212 hasConcept C2778265714 @default.
- W2085128212 hasConcept C2779083432 @default.
- W2085128212 hasConcept C2781263971 @default.
- W2085128212 hasConcept C54355233 @default.
- W2085128212 hasConcept C55493867 @default.
- W2085128212 hasConcept C81885089 @default.
- W2085128212 hasConcept C86803240 @default.
- W2085128212 hasConcept C95444343 @default.
- W2085128212 hasConcept C98274493 @default.
- W2085128212 hasConceptScore W2085128212C104317684 @default.
- W2085128212 hasConceptScore W2085128212C107459253 @default.
- W2085128212 hasConceptScore W2085128212C145103041 @default.
- W2085128212 hasConceptScore W2085128212C153911025 @default.
- W2085128212 hasConceptScore W2085128212C185592680 @default.
- W2085128212 hasConceptScore W2085128212C190283241 @default.
- W2085128212 hasConceptScore W2085128212C2776151105 @default.
- W2085128212 hasConceptScore W2085128212C2776715637 @default.
- W2085128212 hasConceptScore W2085128212C2778004101 @default.
- W2085128212 hasConceptScore W2085128212C2778265714 @default.
- W2085128212 hasConceptScore W2085128212C2779083432 @default.
- W2085128212 hasConceptScore W2085128212C2781263971 @default.
- W2085128212 hasConceptScore W2085128212C54355233 @default.
- W2085128212 hasConceptScore W2085128212C55493867 @default.
- W2085128212 hasConceptScore W2085128212C81885089 @default.
- W2085128212 hasConceptScore W2085128212C86803240 @default.
- W2085128212 hasConceptScore W2085128212C95444343 @default.
- W2085128212 hasConceptScore W2085128212C98274493 @default.
- W2085128212 hasFunder F4320321001 @default.
- W2085128212 hasFunder F4320321106 @default.
- W2085128212 hasFunder F4320321543 @default.
- W2085128212 hasFunder F4320322843 @default.
- W2085128212 hasIssue "2" @default.
- W2085128212 hasLocation W20851282121 @default.
- W2085128212 hasLocation W20851282122 @default.
- W2085128212 hasOpenAccess W2085128212 @default.
- W2085128212 hasPrimaryLocation W20851282121 @default.
- W2085128212 hasRelatedWork W1902655080 @default.