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- W2085137152 abstract "cis-[PtCl2(NH3)2] is the anticancer drug cisplatin, but the iodide analogue cis-[PtI2(NH3)2] is inactive. This inactivity is usually attributed to the greater stability and lower reactivity of Pt−I bonds compared to Pt−Cl in aqueous solution. Interest in reactions of Pt(IV) complexes with thiols arises from the reductive activation of Pt(IV) anticancer drugs in blood plasma. Recently, we found (J. Am. Chem. Soc. 1998, 120, 8253−8254) that low Mr thiols react with Pt(IV)−I bonds of trans,cis-[Pt(en)(OH)2I2] via attack on the coordinated iodo ligand giving rise to reactive chelate-ring-opened Pt(II) ethylenediamine species. Here we report reactions of the Pt(II) and Pt(IV) complexes [Pt(en)I2] and trans,cis-[Pt(en)(OH)2I2] with the major thiol in blood plasma, Cys34 of the protein albumin (66 kDa). Unexpectedly, [Pt(en)I2] reacted more rapidly with albumin than the cisplatin analogue, [Pt(en)Cl2], and did not give products with Pt bound to Cys34. The Pt(IV) chloro analogue, trans,cis-[Pt(en)(OH)2Cl2], did not react at all with albumin. Reactions of trans,cis-[Pt(en)(OH)2I2] with the protein, via direct attack of an iodo ligand on Cys34, gave rise to a relatively stable sulfenic acid derivative, in contrast to reactions with low Mr thiols. Reactions of Pt complexes with thiols in proteins can therefore take a different course: albumin can exert control over the reactivity of Cys34 and stabilize activated derivatives such as the sulfenyl iodide and sulfenic acid. The reactivity of iodide ligands in Pt complexes is much higher than has been previously recognized, and it may be possible to incorporate them into drug design strategies." @default.
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- W2085137152 date "1999-08-25" @default.
- W2085137152 modified "2023-09-23" @default.
- W2085137152 title "Surprising Reactions of Iodo Pt(IV) and Pt(II) Complexes with Human Albumin: Detection of Cys34 Sulfenic Acid" @default.
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- W2085137152 doi "https://doi.org/10.1021/ja990768n" @default.
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