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- W2085142750 abstract "Summary The basal and glucagon-stimulated cyclic adenosine 3′, 5′-monophosphate levels of Morris hepatoma 5123 t.c.(h) have been compared to those of rat liver. Basal levels of this nucleotide were found to be significantly lower in the hepatoma than were those of liver when compared on either a wet weight, dry weight or protein basis. These results are analogous to the findings of numerous studies on transformed cells in culture; they are, however, also unique in that this is the only known in vivo study reporting substantially reduced cyclic adenosine 3′,5′-monophosphate levels in a solid, transplantable hepatoma. Administration of glucagon to tumor-bearing rats produced only a 2-fold increase in the hepatoma cyclic adenosine 3′,5′-monophosphate levels compared to a 37-fold rise in liver, suggesting that this tumor's adenylate cyclase is less responsive to glucagon stimulation than is that of liver." @default.
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- W2085142750 date "1974-07-01" @default.
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- W2085142750 title "Decreased basal cyclic adenosine 3′,5′-monophosphate levels in Morris hepatoma 5123 t.c.(h)" @default.
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- W2085142750 doi "https://doi.org/10.1016/s0006-291x(74)80189-0" @default.
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