FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085145938> ?p ?o ?g. }

• W2085145938 endingPage "477" @default.
• W2085145938 startingPage "469" @default.
• W2085145938 abstract "Voltage-gated sodium channels (Na(V)s) are essential in propagating neuronal electrical impulse and triggering muscle contraction. In the heart, the Na(+) channel isoform Na(V)1.5 is strongly expressed and in the past was thought to be solely responsible for generating the cardiac Na(+) current (I(Na)). Recent studies, however, revealed that neuronal and skeletal muscle Na(+) channel isoforms are also expressed in the heart and contribute to cardiac I(Na). Amongst the findings is that many neuronal type Na(V)s are expressed in specific areas of the conduction system and ventricles. The contribution of these TTX-sensitive channels to normal cardiac function remains unclear but these data raise the possibility of a more prominent role of TTX-sensitive channels in conduction. Moreover, cardiac arrhythmias are commonly observed in many neuronal and musculoskeletal diseases despite their exclusive linkage to mutations in the neuronal and skeletal muscle sodium channel isoforms. The cause for these arrhythmias remains poorly understood. These recent findings indicate that neuronal and skeletal muscle sodium channels are expressed in areas of the heart that may be involved in the clinical phenotypes observed. The purpose of this review is to give an overview of the evidence for the presence of TTX-sensitive Na(V) isoforms in the heart and present the hypothesis brought forward so far for their direct role in cardiac function. These data demonstrate the promiscuous nature of the cardiac sodium current at the molecular level and should help us to bridge the gap that exists between our understanding of cardiac physiology and arrhythmias associated to brain and myotonic diseases." @default.
• W2085145938 created "2016-06-24" @default.
• W2085145938 creator A5032701563 @default.
• W2085145938 creator A5057991190 @default.
• W2085145938 creator A5062732712 @default.
• W2085145938 date "2007-03-01" @default.
• W2085145938 modified "2023-09-23" @default.
• W2085145938 title "The promiscuous nature of the cardiac sodium current" @default.
• W2085145938 cites W12335816 @default.
• W2085145938 cites W1491803208 @default.
• W2085145938 cites W1507105217 @default.
• W2085145938 cites W1538804701 @default.
• W2085145938 cites W1575061116 @default.
• W2085145938 cites W1591932185 @default.
• W2085145938 cites W1632243207 @default.
• W2085145938 cites W1699466138 @default.
• W2085145938 cites W1903925553 @default.
• W2085145938 cites W1964741942 @default.
• W2085145938 cites W1965278819 @default.
• W2085145938 cites W1965805867 @default.
• W2085145938 cites W1970599367 @default.
• W2085145938 cites W1974128841 @default.
• W2085145938 cites W1974842872 @default.
• W2085145938 cites W1976504173 @default.
• W2085145938 cites W1983187084 @default.
• W2085145938 cites W1985150523 @default.
• W2085145938 cites W1986189584 @default.
• W2085145938 cites W1986756807 @default.
• W2085145938 cites W1989906944 @default.
• W2085145938 cites W1991662012 @default.
• W2085145938 cites W1991798507 @default.
• W2085145938 cites W1997893262 @default.
• W2085145938 cites W2007144587 @default.
• W2085145938 cites W2007289876 @default.
• W2085145938 cites W2009512836 @default.
• W2085145938 cites W2009636237 @default.
• W2085145938 cites W2016837051 @default.
• W2085145938 cites W2018642624 @default.
• W2085145938 cites W2021784783 @default.
• W2085145938 cites W2025173962 @default.
• W2085145938 cites W2027085605 @default.
• W2085145938 cites W2027165348 @default.
• W2085145938 cites W2028710069 @default.
• W2085145938 cites W2029988619 @default.
• W2085145938 cites W2029995140 @default.
• W2085145938 cites W2032590600 @default.
• W2085145938 cites W2034475225 @default.
• W2085145938 cites W2036921486 @default.
• W2085145938 cites W2037543671 @default.
• W2085145938 cites W2039737587 @default.
• W2085145938 cites W2043707154 @default.
• W2085145938 cites W2049229245 @default.
• W2085145938 cites W2051237605 @default.
• W2085145938 cites W2054336104 @default.
• W2085145938 cites W2064461784 @default.
• W2085145938 cites W2070216424 @default.
• W2085145938 cites W2074705578 @default.
• W2085145938 cites W2075746798 @default.
• W2085145938 cites W2085873341 @default.
• W2085145938 cites W2086217307 @default.
• W2085145938 cites W2090079352 @default.
• W2085145938 cites W2093214695 @default.
• W2085145938 cites W2093297294 @default.
• W2085145938 cites W2096511095 @default.
• W2085145938 cites W2105172736 @default.
• W2085145938 cites W2105498897 @default.
• W2085145938 cites W2107786385 @default.
• W2085145938 cites W2111880897 @default.
• W2085145938 cites W2114457659 @default.
• W2085145938 cites W2115052737 @default.
• W2085145938 cites W2116051448 @default.
• W2085145938 cites W2120440113 @default.
• W2085145938 cites W2125843035 @default.
• W2085145938 cites W2126663982 @default.
• W2085145938 cites W2130438756 @default.
• W2085145938 cites W2131871260 @default.
• W2085145938 cites W2132443888 @default.
• W2085145938 cites W2135271579 @default.
• W2085145938 cites W2139501473 @default.
• W2085145938 cites W2140099759 @default.
• W2085145938 cites W2140773950 @default.
• W2085145938 cites W2150142099 @default.
• W2085145938 cites W2155365016 @default.
• W2085145938 cites W2159258890 @default.
• W2085145938 cites W2161602976 @default.
• W2085145938 cites W2228644631 @default.
• W2085145938 cites W2401933974 @default.
• W2085145938 cites W4235596624 @default.
• W2085145938 cites W4248477248 @default.
• W2085145938 cites W4300374597 @default.
• W2085145938 doi "https://doi.org/10.1016/j.yjmcc.2006.12.005" @default.
• W2085145938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17289073" @default.
• W2085145938 hasPublicationYear "2007" @default.
• W2085145938 type Work @default.
• W2085145938 sameAs 2085145938 @default.
• W2085145938 citedByCount "47" @default.
• W2085145938 countsByYear W20851459382012 @default.
• W2085145938 countsByYear W20851459382013 @default.

• next