FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085151479> ?p ?o ?g. }

• W2085151479 endingPage "156" @default.
• W2085151479 startingPage "155" @default.
• W2085151479 abstract "The tropane alkaloids are a well-recognized group of structurally related natural products and have long been known to have anticholinergic, antiemetic, parasympatholytic, anesthetic, and many other actions. This class of alkaloid includes such important medicinal alkaloids as cocaine, scopolamine, and atropine. In 1988, polyhydroxylated nor tropane alkaloids were discovered as plant metabolic mediators in the rhizosphere from Calystegia sepium (Convolvulaceae) and given the trivial names calystegines (Tepfer et al., 1988). In the course of isolation of 1-deoxynojirimycin from mulberry plants, we found calystegines B 2 and C 1 , and that these compounds had potent glycosidase inhibitory activity (Asano et al., 1994a,b). This prompted us to search for other calystegines from a wide range of plants. The genera Atropa, Datura, Duboisia, Hyoscyamus, and Scopolia, which belong to the Solanaccae, are especially rich sources of tropane alkaloids. Calystegines have now been found in all these genera and even in most genera of the Solanaceae (Molyneux et al., 1996; Nash et al., 1996). Surprisingly, a traditional Chinese crude drug 'Ti-koppi', which is the root barks of Lycium chinense (Solanaceae), contained many kinds of calystegines such as calystegines A 3 ,A 5 , A 6 , A 7 , B 1 , B 2 , B 3 , B 4 , B 5 , C 1 , C 2 , N and N-methyl-calystegines B 2 and C, (Asano et al., 1997a). Some calystegines are potent inhibitors of β-glucosidase and α-galactosidase with IC 50 values ranging 10 -6 -10 7 M. There are many edible fruits and vegetables in the families Solanaceae and Convolvulaceae. A particularly interesting aspect of the biological activity of calystegines is their potential toxicity toward humans which ingest them. It is possible that the calystegines, which inhibit β-glucosidase and α-galactosidase, might produce syndromes that mimic a genetic deficiency of such activities, namely, Gaucher and Fabry diseases, respectively. We surveyed the occurrence of calystegines in edible fruits and vegetables, and detected some of calystegines A 3 , B 1 , B 2 , and C 1 or all from all samples in the Solanaceae and Convolvulaceae tested (Asano et al., 1997b). The presence of calystegines in human foods such as tomatoes, potatoes, eggplants, and sweet potatoes poses the question as to the effect that these compounds might have on humans. Although calystegines B 1 and C 1 potently inhibited human liver lysosomal β-glucosidase, preliminary experiments have indicated that they do not cause additional lysosomal storage in human fibroblasts in culture for 1 week in the presence of 1 mM of the calystegine. Interestingly, a quite recent work indicates that calystegine B 2 , which is a good inhibitor of human lysosomal α-galactosidase A (a-Gal A) with an IC 50 value of 30 μM, enhances the enzyme activity in lymphoblasts derived from Fabry patients with the R301Q mutation identified in cardiac Fabry patients. The enzyme activity was increased fivefold by cultivation with calystegine B 2 at 1 mM." @default.
• W2085151479 created "2016-06-24" @default.
• W2085151479 creator A5078914737 @default.
• W2085151479 date "2000-07-01" @default.
• W2085151479 modified "2023-10-10" @default.
• W2085151479 title "Water soluble nortropane alkaloids in crude drugs, edible fruits and vegetables: biological activities and therapeutic applications" @default.
• W2085151479 cites W1994334199 @default.
• W2085151479 cites W2047240492 @default.
• W2085151479 cites W2123121640 @default.
• W2085151479 cites W2161749694 @default.
• W2085151479 cites W2171967505 @default.
• W2085151479 doi "https://doi.org/10.1016/s0047-6374(00)00143-3" @default.
• W2085151479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10996015" @default.
• W2085151479 hasPublicationYear "2000" @default.
• W2085151479 type Work @default.
• W2085151479 sameAs 2085151479 @default.
• W2085151479 citedByCount "10" @default.
• W2085151479 countsByYear W20851514792013 @default.
• W2085151479 countsByYear W20851514792014 @default.
• W2085151479 countsByYear W20851514792015 @default.
• W2085151479 countsByYear W20851514792016 @default.
• W2085151479 countsByYear W20851514792018 @default.
• W2085151479 countsByYear W20851514792019 @default.
• W2085151479 countsByYear W20851514792020 @default.
• W2085151479 countsByYear W20851514792021 @default.
• W2085151479 crossrefType "journal-article" @default.
• W2085151479 hasAuthorship W2085151479A5078914737 @default.
• W2085151479 hasConcept C185592680 @default.
• W2085151479 hasConcept C31903555 @default.
• W2085151479 hasConcept C556039675 @default.
• W2085151479 hasConcept C71924100 @default.
• W2085151479 hasConceptScore W2085151479C185592680 @default.
• W2085151479 hasConceptScore W2085151479C31903555 @default.
• W2085151479 hasConceptScore W2085151479C556039675 @default.
• W2085151479 hasConceptScore W2085151479C71924100 @default.
• W2085151479 hasIssue "2-3" @default.
• W2085151479 hasLocation W20851514791 @default.
• W2085151479 hasLocation W20851514792 @default.
• W2085151479 hasOpenAccess W2085151479 @default.
• W2085151479 hasPrimaryLocation W20851514791 @default.
• W2085151479 hasRelatedWork W1531601525 @default.
• W2085151479 hasRelatedWork W2319480705 @default.
• W2085151479 hasRelatedWork W2384464875 @default.
• W2085151479 hasRelatedWork W2398689458 @default.
• W2085151479 hasRelatedWork W2606230654 @default.
• W2085151479 hasRelatedWork W2607424097 @default.
• W2085151479 hasRelatedWork W2748952813 @default.
• W2085151479 hasRelatedWork W2899084033 @default.
• W2085151479 hasRelatedWork W2948807893 @default.
• W2085151479 hasRelatedWork W2778153218 @default.
• W2085151479 hasVolume "116" @default.
• W2085151479 isParatext "false" @default.
• W2085151479 isRetracted "false" @default.
• W2085151479 magId "2085151479" @default.
• W2085151479 workType "article" @default.