FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085151567> ?p ?o ?g. }

• W2085151567 endingPage "134" @default.
• W2085151567 startingPage "129" @default.
• W2085151567 abstract "The development of atherosclerotic lesions is mainly due to macrophage death. The oxidative stresses of monocytes/macrophages play a vital role in the initiation and amplification of atherosclerosis. Apamin, a component of bee venom, exerts an anti-inflammatory effect, and selectively inhibits the Ca(2+)-activated K(+) channels. The mechanisms involved in the inhibition of macrophage apoptosis have been fully elucidated. We induced oxidized low-density lipoprotein (oxLDL) in THP-1-derived macrophage and studied the effect of apamin on intercellular lipid levels, mitochondria-related apoptotic pathway and numbers of apoptotic cells. Oil-red O staining indicates that the inhibition of apamin in the condition significantly prevents intracellular lipid deposition. Treatment with apamin significantly decreased the apoptotic macrophages by decreasing the expression of pro-apoptotic genes Bax, caspase-3 and PARP protein levels, as well as through increasing expression of anti-apoptotic genes Bcl-2 and Bcl-xL protein levels in the absence and presence of oxLDL. In vivo, with apamin treatment reduced apoptotic cells death by TUNEL staining. These results indicate that apamin plays an important role in monocyte/macrophage apoptotic processing, which may provide a potential drug for preventing atherosclerosis." @default.
• W2085151567 created "2016-06-24" @default.
• W2085151567 creator A5000976267 @default.
• W2085151567 creator A5001270427 @default.
• W2085151567 creator A5013625097 @default.
• W2085151567 creator A5018899207 @default.
• W2085151567 creator A5045589392 @default.
• W2085151567 creator A5054300719 @default.
• W2085151567 creator A5057326363 @default.
• W2085151567 creator A5074259331 @default.
• W2085151567 date "2012-08-01" @default.
• W2085151567 modified "2023-10-18" @default.
• W2085151567 title "Apamin inhibits THP-1-derived macrophage apoptosis via mitochondria-related apoptotic pathway" @default.
• W2085151567 cites W1607777232 @default.
• W2085151567 cites W1977109672 @default.
• W2085151567 cites W1978666859 @default.
• W2085151567 cites W1984104244 @default.
• W2085151567 cites W1984180403 @default.
• W2085151567 cites W2000965794 @default.
• W2085151567 cites W2005861034 @default.
• W2085151567 cites W2006710293 @default.
• W2085151567 cites W2007902031 @default.
• W2085151567 cites W2015424171 @default.
• W2085151567 cites W2031934833 @default.
• W2085151567 cites W2033873142 @default.
• W2085151567 cites W2045563337 @default.
• W2085151567 cites W2049653248 @default.
• W2085151567 cites W2053400956 @default.
• W2085151567 cites W2061645487 @default.
• W2085151567 cites W2079820607 @default.
• W2085151567 cites W2091337398 @default.
• W2085151567 cites W2094941678 @default.
• W2085151567 cites W2106658253 @default.
• W2085151567 cites W2115457290 @default.
• W2085151567 cites W2143339542 @default.
• W2085151567 cites W2157051245 @default.
• W2085151567 cites W2161682643 @default.
• W2085151567 cites W2163431279 @default.
• W2085151567 cites W2164522756 @default.
• W2085151567 cites W2165451456 @default.
• W2085151567 cites W2166383818 @default.
• W2085151567 doi "https://doi.org/10.1016/j.yexmp.2012.04.003" @default.
• W2085151567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22537544" @default.
• W2085151567 hasPublicationYear "2012" @default.
• W2085151567 type Work @default.
• W2085151567 sameAs 2085151567 @default.
• W2085151567 citedByCount "23" @default.
• W2085151567 countsByYear W20851515672014 @default.
• W2085151567 countsByYear W20851515672015 @default.
• W2085151567 countsByYear W20851515672017 @default.
• W2085151567 countsByYear W20851515672018 @default.
• W2085151567 countsByYear W20851515672020 @default.
• W2085151567 countsByYear W20851515672021 @default.
• W2085151567 countsByYear W20851515672022 @default.
• W2085151567 countsByYear W20851515672023 @default.
• W2085151567 crossrefType "journal-article" @default.
• W2085151567 hasAuthorship W2085151567A5000976267 @default.
• W2085151567 hasAuthorship W2085151567A5001270427 @default.
• W2085151567 hasAuthorship W2085151567A5013625097 @default.
• W2085151567 hasAuthorship W2085151567A5018899207 @default.
• W2085151567 hasAuthorship W2085151567A5045589392 @default.
• W2085151567 hasAuthorship W2085151567A5054300719 @default.
• W2085151567 hasAuthorship W2085151567A5057326363 @default.
• W2085151567 hasAuthorship W2085151567A5074259331 @default.
• W2085151567 hasConcept C134018914 @default.
• W2085151567 hasConcept C153911025 @default.
• W2085151567 hasConcept C185592680 @default.
• W2085151567 hasConcept C190283241 @default.
• W2085151567 hasConcept C202751555 @default.
• W2085151567 hasConcept C204258353 @default.
• W2085151567 hasConcept C2776919887 @default.
• W2085151567 hasConcept C2779244956 @default.
• W2085151567 hasConcept C28859421 @default.
• W2085151567 hasConcept C54355233 @default.
• W2085151567 hasConcept C55493867 @default.
• W2085151567 hasConcept C79879829 @default.
• W2085151567 hasConcept C81885089 @default.
• W2085151567 hasConcept C83743174 @default.
• W2085151567 hasConcept C86803240 @default.
• W2085151567 hasConcept C95444343 @default.
• W2085151567 hasConceptScore W2085151567C134018914 @default.
• W2085151567 hasConceptScore W2085151567C153911025 @default.
• W2085151567 hasConceptScore W2085151567C185592680 @default.
• W2085151567 hasConceptScore W2085151567C190283241 @default.
• W2085151567 hasConceptScore W2085151567C202751555 @default.
• W2085151567 hasConceptScore W2085151567C204258353 @default.
• W2085151567 hasConceptScore W2085151567C2776919887 @default.
• W2085151567 hasConceptScore W2085151567C2779244956 @default.
• W2085151567 hasConceptScore W2085151567C28859421 @default.
• W2085151567 hasConceptScore W2085151567C54355233 @default.
• W2085151567 hasConceptScore W2085151567C55493867 @default.
• W2085151567 hasConceptScore W2085151567C79879829 @default.
• W2085151567 hasConceptScore W2085151567C81885089 @default.
• W2085151567 hasConceptScore W2085151567C83743174 @default.
• W2085151567 hasConceptScore W2085151567C86803240 @default.
• W2085151567 hasConceptScore W2085151567C95444343 @default.
• W2085151567 hasIssue "1" @default.
• W2085151567 hasLocation W20851515671 @default.

• next