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- W2085155202 abstract "Since the introduction of the original prontosil by Domagk 1 as a therapeutic agent against hemolytic streptococci in mice, its two derivatives prontosil soluble and sulfanilamide have been extensively used against a variety of infections in man. Experimental evidence by Rosenthal, 2 by Cooper, Gross and Mellon 3 and by Cooper and Gross 4 show that sulfanilamide has distinctly therapeutic properties in rats and mice infected with the type III pneumococcus. Heintzelman, Hadley and Mellon 5 reported a small series of nineteen cases of type III pneumococcus lobar pneumonia, which carries a high mortality in the Pittsburgh area. Of nine patients who received sulfanilamide, seven lived and two died, while of the remaining untreated patients eight died and two recovered. At the Meadowbrook Hospital 6 a crisis was induced by sulfanilamide twenty-four hours after onset of a type III lobar pneumonia, which was contrary to our experience with the disease" @default.
- W2085155202 created "2016-06-24" @default.
- W2085155202 creator A5021322674 @default.
- W2085155202 date "1937-12-25" @default.
- W2085155202 modified "2023-09-27" @default.
- W2085155202 title "THE INTRATHECAL USE OF PRONTOSIL SOLUBLE" @default.
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- W2085155202 doi "https://doi.org/10.1001/jama.1937.02780520028007" @default.
- W2085155202 hasPublicationYear "1937" @default.
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