Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085163003> ?p ?o ?g. }
- W2085163003 endingPage "2524" @default.
- W2085163003 startingPage "2515" @default.
- W2085163003 abstract "This study was aimed to evaluate the involvement of CB2 cannabinoid receptors (CB2r) in the rewarding, reinforcing and motivational effects of nicotine. Conditioned place preference (CPP) and intravenous self-administration experiments were carried out in knockout mice lacking CB2r (CB2KO) and wild-type (WT) littermates treated with the CB2r antagonist AM630 (1 and 3 mg/kg). Gene expression analyses of tyrosine hydroxylase (TH) and α3- and α4-nicotinic acetylcholine receptor subunits (nAChRs) in the ventral tegmental area (VTA) and immunohistochemical studies to elucidate whether CB2r colocalized with α3- and α4-nAChRs in the nucleus accumbens and VTA were performed. Mecamylamine-precipitated withdrawal syndrome after chronic nicotine exposure was evaluated in CB2KO mice and WT mice treated with AM630 (1 and 3 mg/kg). CB2KO mice did not show nicotine-induced place conditioning and self-administered significantly less nicotine. In addition, AM630 was able to block (3 mg/kg) nicotine-induced CPP and reduce (1 and 3 mg/kg) nicotine self-administration. Under baseline conditions, TH, α3-nAChR, and α4-nAChR mRNA levels in the VTA of CB2KO mice were significantly lower compared with WT mice. Confocal microscopy images revealed that CB2r colocalized with α3- and α4-nAChRs. Somatic signs of nicotine withdrawal (rearings, groomings, scratches, teeth chattering, and body tremors) increased significantly in WT but were absent in CB2KO mice. Interestingly, the administration of AM630 blocked the nicotine withdrawal syndrome and failed to alter basal behavior in saline-treated WT mice. These results suggest that CB2r play a relevant role in the rewarding, reinforcing, and motivational effects of nicotine. Pharmacological manipulation of this receptor deserves further consideration as a potential new valuable target for the treatment of nicotine dependence." @default.
- W2085163003 created "2016-06-24" @default.
- W2085163003 creator A5004097414 @default.
- W2085163003 creator A5020787270 @default.
- W2085163003 creator A5037897982 @default.
- W2085163003 creator A5038192955 @default.
- W2085163003 creator A5039909038 @default.
- W2085163003 creator A5052409847 @default.
- W2085163003 creator A5066933181 @default.
- W2085163003 creator A5066939418 @default.
- W2085163003 creator A5072251228 @default.
- W2085163003 creator A5073532676 @default.
- W2085163003 creator A5088955793 @default.
- W2085163003 date "2013-07-02" @default.
- W2085163003 modified "2023-10-18" @default.
- W2085163003 title "Role of CB2 Cannabinoid Receptors in the Rewarding, Reinforcing, and Physical Effects of Nicotine" @default.
- W2085163003 cites W1491932783 @default.
- W2085163003 cites W1539023805 @default.
- W2085163003 cites W1635375164 @default.
- W2085163003 cites W1965739631 @default.
- W2085163003 cites W1972302331 @default.
- W2085163003 cites W1976458982 @default.
- W2085163003 cites W1978262730 @default.
- W2085163003 cites W1978355813 @default.
- W2085163003 cites W1980460968 @default.
- W2085163003 cites W1980917285 @default.
- W2085163003 cites W1983885464 @default.
- W2085163003 cites W1989152115 @default.
- W2085163003 cites W1989353122 @default.
- W2085163003 cites W1999733213 @default.
- W2085163003 cites W2001109168 @default.
- W2085163003 cites W2002722641 @default.
- W2085163003 cites W2014344171 @default.
- W2085163003 cites W2020171179 @default.
- W2085163003 cites W2026290368 @default.
- W2085163003 cites W2028354601 @default.
- W2085163003 cites W2033423176 @default.
- W2085163003 cites W2046545299 @default.
- W2085163003 cites W2050041101 @default.
- W2085163003 cites W2052825352 @default.
- W2085163003 cites W2055686857 @default.
- W2085163003 cites W2055969312 @default.
- W2085163003 cites W2061548808 @default.
- W2085163003 cites W2063065213 @default.
- W2085163003 cites W2064507133 @default.
- W2085163003 cites W2067382805 @default.
- W2085163003 cites W2069500090 @default.
- W2085163003 cites W2081950565 @default.
- W2085163003 cites W2081997259 @default.
- W2085163003 cites W2083076890 @default.
- W2085163003 cites W2086781281 @default.
- W2085163003 cites W2092939280 @default.
- W2085163003 cites W2097682864 @default.
- W2085163003 cites W2100598248 @default.
- W2085163003 cites W2104703779 @default.
- W2085163003 cites W2107277218 @default.
- W2085163003 cites W2111761092 @default.
- W2085163003 cites W2112994833 @default.
- W2085163003 cites W2127241683 @default.
- W2085163003 cites W2134842419 @default.
- W2085163003 cites W2139155720 @default.
- W2085163003 cites W2141246891 @default.
- W2085163003 cites W4231752535 @default.
- W2085163003 cites W765128932 @default.
- W2085163003 doi "https://doi.org/10.1038/npp.2013.157" @default.
- W2085163003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3799072" @default.
- W2085163003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23817165" @default.
- W2085163003 hasPublicationYear "2013" @default.
- W2085163003 type Work @default.
- W2085163003 sameAs 2085163003 @default.
- W2085163003 citedByCount "104" @default.
- W2085163003 countsByYear W20851630032014 @default.
- W2085163003 countsByYear W20851630032015 @default.
- W2085163003 countsByYear W20851630032016 @default.
- W2085163003 countsByYear W20851630032017 @default.
- W2085163003 countsByYear W20851630032018 @default.
- W2085163003 countsByYear W20851630032019 @default.
- W2085163003 countsByYear W20851630032020 @default.
- W2085163003 countsByYear W20851630032021 @default.
- W2085163003 countsByYear W20851630032022 @default.
- W2085163003 countsByYear W20851630032023 @default.
- W2085163003 crossrefType "journal-article" @default.
- W2085163003 hasAuthorship W2085163003A5004097414 @default.
- W2085163003 hasAuthorship W2085163003A5020787270 @default.
- W2085163003 hasAuthorship W2085163003A5037897982 @default.
- W2085163003 hasAuthorship W2085163003A5038192955 @default.
- W2085163003 hasAuthorship W2085163003A5039909038 @default.
- W2085163003 hasAuthorship W2085163003A5052409847 @default.
- W2085163003 hasAuthorship W2085163003A5066933181 @default.
- W2085163003 hasAuthorship W2085163003A5066939418 @default.
- W2085163003 hasAuthorship W2085163003A5072251228 @default.
- W2085163003 hasAuthorship W2085163003A5073532676 @default.
- W2085163003 hasAuthorship W2085163003A5088955793 @default.
- W2085163003 hasBestOaLocation W20851630031 @default.
- W2085163003 hasConcept C126322002 @default.
- W2085163003 hasConcept C134018914 @default.
- W2085163003 hasConcept C137183658 @default.
- W2085163003 hasConcept C148001335 @default.