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• W2085163663 startingPage "8114" @default.
• W2085163663 abstract "Charge-conversional naturally occurring chitosan–agmatine bioconjugates are prepared by dimethylmaleic anhydride (DMA) modification and the nucleophilic reaction between tosyl of tosylated chitosan and primary amine of agmatine. These bioconjugates (CS-DM-Agm) are shown to condense siRNA into nanocomplexes, which are stable in the presence of serum at physical pH values. Furthermore, the surface charge of complexes can tune from negative to positive while pH is changed to weak acid tumor micromilieu, thus facilitating the target cancer cell internalization in resisting serum adsorption. More importantly, this smart biogenic system shows remarkable gene silencing efficiency and a high apoptotic rate of tumor cells both in vitro and in vivo, indicating its great potential for cancer therapy." @default.
• W2085163663 created "2016-06-24" @default.
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• W2085163663 creator A5061325682 @default.
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• W2085163663 date "2015-04-08" @default.
• W2085163663 modified "2023-10-10" @default.
• W2085163663 title "Enhanced Therapeutic siRNA to Tumor Cells by a pH-Sensitive Agmatine–Chitosan Bioconjugate" @default.
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• W2085163663 doi "https://doi.org/10.1021/acsami.5b00851" @default.
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• W2085163663 hasPublicationYear "2015" @default.
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