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• W2085165670 endingPage "121" @default.
• W2085165670 startingPage "115" @default.
• W2085165670 abstract "Single-stranded (ss) oligodeoxyribonucleotides (oligos) containing both Watson-Crick and Hoogsteen hydrogen bonding domains joined by either a 5-nucleotide loop or a flexible hexaethylene-glycol linker, called foldback triplex-forming oligos (FTFOs), are designed and studied for their binding affinity and specificity to their ss DNA/RNA targets. Thermal denaturation studies revealed an increased affinity of FTFOs, due to addition of a Hoogsteen hydrogen bonding domain at the binding site, as the Watson-Crick domain forms a double helix with the target, when compared to conventional antisense and antigene oligos. DNase I hydrolysis and electrophoretic mobility shift analysis confirmed the formation of foldback triplexes relative to conventional double- and triple-stranded structures. The FTFOs showed increased sequence specificity mainly arising from their ability to recognize the target sequence twice, first by Watson-Crick base pairing and a second time by Hoogsteen base pairing. An FTFO with DNA components in both duplex- and triplexforming domains showed preference for a DNA homopurine target strand." @default.
• W2085165670 created "2016-06-24" @default.
• W2085165670 creator A5069014764 @default.
• W2085165670 creator A5088791437 @default.
• W2085165670 date "1994-11-01" @default.
• W2085165670 modified "2023-10-12" @default.
• W2085165670 title "Single-strand-targeted triplex formation: stability, specificity and RNase H activation properties" @default.
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• W2085165670 doi "https://doi.org/10.1016/0378-1119(94)90419-7" @default.
• W2085165670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7525410" @default.
• W2085165670 hasPublicationYear "1994" @default.
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