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• W2085167010 endingPage "810" @default.
• W2085167010 startingPage "799" @default.
• W2085167010 abstract "Toll-like receptors (TLRs) are the most important class of innate pattern recognition receptors (PRRs) by which host immune and non-immune cells are able to recognize pathogen-associated molecular patterns (PAMPs). Most mammalian species have 10 to 15 types of TLRs. TLRs are believed to function as homo- or hetero-dimers. TLR2, which plays a crucial role in recognizing PAMPs from Staphylococcus aureus, forms heterodimers with TLR1 or TLR6 and each dimer has a different ligand specificity. Staphylococcal lipoproteins, Panton-Valentine toxin and Phenol Soluble Modulins have been identified as potent TLR2 ligands. Conversely, the ligand function attributed to peptidoglycan and LTA remains controversial. TLR2 uses a MyD88-dependent signaling pathway that results in NF-kB translocation into the nucleus and activation of the expression of pro-inflammatory cytokine genes. Recognition rouses both an inflammatory response, culminating in the phagocytosis of bacteria, and an adaptive immune response, with the presentation of resulting bacterial compounds to T cells. Here, recent advances on the recognition of S. aureus by TLRs are presented and discussed, as well as the new therapeutic opportunities deriving from this new knowledge." @default.
• W2085167010 created "2016-06-24" @default.
• W2085167010 creator A5006511946 @default.
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• W2085167010 creator A5041132942 @default.
• W2085167010 creator A5062138808 @default.
• W2085167010 creator A5074636544 @default.
• W2085167010 date "2011-09-01" @default.
• W2085167010 modified "2023-10-14" @default.
• W2085167010 title "Toll-Like Receptors (TLRs) in Innate Immune Defense Against <i>Staphylococcus Aureus</i>" @default.
• W2085167010 cites W112763288 @default.
• W2085167010 cites W1492895367 @default.
• W2085167010 cites W1576071600 @default.
• W2085167010 cites W1590936677 @default.
• W2085167010 cites W15919647 @default.
• W2085167010 cites W1722925949 @default.
• W2085167010 cites W1855459482 @default.
• W2085167010 cites W1868786445 @default.
• W2085167010 cites W1897249974 @default.
• W2085167010 cites W1925757606 @default.
• W2085167010 cites W1929604946 @default.
• W2085167010 cites W193362461 @default.
• W2085167010 cites W1938680410 @default.
• W2085167010 cites W1963751749 @default.
• W2085167010 cites W1964531685 @default.
• W2085167010 cites W1964718835 @default.
• W2085167010 cites W1968182403 @default.
• W2085167010 cites W1974322322 @default.
• W2085167010 cites W1974668730 @default.
• W2085167010 cites W1981837371 @default.
• W2085167010 cites W1987664943 @default.
• W2085167010 cites W1995744610 @default.
• W2085167010 cites W1996671942 @default.
• W2085167010 cites W2000919345 @default.
• W2085167010 cites W2004465286 @default.
• W2085167010 cites W2008152503 @default.
• W2085167010 cites W2008808919 @default.
• W2085167010 cites W2011211995 @default.
• W2085167010 cites W2012005937 @default.
• W2085167010 cites W2019056562 @default.
• W2085167010 cites W2019175181 @default.
• W2085167010 cites W2034640788 @default.
• W2085167010 cites W203647327 @default.
• W2085167010 cites W2036767516 @default.
• W2085167010 cites W2041505362 @default.
• W2085167010 cites W2044750677 @default.
• W2085167010 cites W2048850910 @default.
• W2085167010 cites W2048924183 @default.
• W2085167010 cites W2049876536 @default.
• W2085167010 cites W2055815963 @default.
• W2085167010 cites W2056018607 @default.
• W2085167010 cites W2060441844 @default.
• W2085167010 cites W206211047 @default.
• W2085167010 cites W2069663822 @default.
• W2085167010 cites W2070782085 @default.
• W2085167010 cites W2075145828 @default.
• W2085167010 cites W2075427300 @default.
• W2085167010 cites W2076586795 @default.
• W2085167010 cites W2083119828 @default.
• W2085167010 cites W2090859543 @default.
• W2085167010 cites W2094124133 @default.
• W2085167010 cites W2096210882 @default.
• W2085167010 cites W2096680219 @default.
• W2085167010 cites W2098650503 @default.
• W2085167010 cites W2100345001 @default.
• W2085167010 cites W2102694854 @default.
• W2085167010 cites W2103358704 @default.
• W2085167010 cites W2103783390 @default.
• W2085167010 cites W2103851091 @default.
• W2085167010 cites W2107250639 @default.
• W2085167010 cites W2110768898 @default.
• W2085167010 cites W2111154143 @default.
• W2085167010 cites W2115185894 @default.
• W2085167010 cites W2120610777 @default.
• W2085167010 cites W2124145819 @default.
• W2085167010 cites W2125945390 @default.
• W2085167010 cites W2126552441 @default.
• W2085167010 cites W2126829776 @default.
• W2085167010 cites W2127336616 @default.
• W2085167010 cites W2130946949 @default.
• W2085167010 cites W2136390652 @default.
• W2085167010 cites W2138666908 @default.
• W2085167010 cites W2139655699 @default.
• W2085167010 cites W2141040025 @default.
• W2085167010 cites W2145078103 @default.
• W2085167010 cites W2145584783 @default.
• W2085167010 cites W2145803213 @default.
• W2085167010 cites W2147978858 @default.
• W2085167010 cites W2148579227 @default.
• W2085167010 cites W2158500759 @default.
• W2085167010 cites W2160317538 @default.
• W2085167010 cites W2162593826 @default.
• W2085167010 cites W2169198924 @default.
• W2085167010 cites W2170720109 @default.
• W2085167010 cites W2192688319 @default.
• W2085167010 cites W2262976603 @default.

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