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• W2085169612 abstract "Employing enhanced chemiluminescence in luminol-p-iodophenol peroxidase system and coumarine-3-carboxylic acid, it was shown that guanosine-5′-monophosphate (GMP) appreciably reduces formation of H2O2 and hydroxyl radicals induced by x-ray irradiation. Using immunoenzyme assay, we revealed that GMP lowered 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) formation in DNA in vitro after irradiation. The results of survival test have shown that mice being injected intraperitoneally with GMP after irradiation with a dose of 7 Gy had better survival rate than the control mice. GMP reduced leucopoenia and thrombocytopenia in irradiated mice. Obtained results give premises that GMP may be promising therapeutic agent for treatment of radiation injuries." @default.
• W2085169612 created "2016-06-24" @default.
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• W2085169612 date "2010-10-06" @default.
• W2085169612 modified "2023-10-02" @default.
• W2085169612 title "Antioxidative and Radiation Modulating Properties of Guanosine-5′-Monophosphate" @default.
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• W2085169612 doi "https://doi.org/10.1080/15257770.2010.518576" @default.
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