FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085172008> ?p ?o ?g. }

• W2085172008 endingPage "1" @default.
• W2085172008 startingPage "1" @default.
• W2085172008 abstract "Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in industrialized countries. It has no accepted medical therapy. Fatty acid-bile acid conjugates (FABACs) were proven to prevent diet-induced NAFLD in rodents.This study was undertaken to test whether oral FABACs are also effective in reducing liver fat in preestablished diet-induced NAFLD.NAFLD was induced in mice and rats by a high-fat diet and maintained by various proportions thereof. The FABACs used were conjugates of cholic acid with either arachidic or stearic acids.FABAC therapy reduced liver fat in all four series of experiments. The rapidity of the effect was inversely proportional to the concentration of fat in the maintenance diet. In mice on a 25% maintenance diet FABACs decreased total liver lipids by about 30% in 4 weeks (P<0.03). Diglycerides (P<0.003) and triglycerides (P<0.01) were the main neutral liver lipids that decreased during FABAC therapy. Both FABACs tested reduced liver fat in NAFLD at doses of 25 and 150 mg/kg/day. High-fat diet increased, whereas FABAC therapy decreased plasma 16 : 1/(16 : 0+16 : 1) fatty acid ratio - a marker of stearoyl CoA desaturase activity. In HepG2 cells FABACs decreased de-novo fatty acid synthesis dose dependently.Oral FABAC therapy decreased liver fat in preestablished NAFLD in mice and rats. Inhibition of stearoyl CoA desaturase activity and fatty acid synthesis are mechanisms that may contribute to this decrease. FABACs may be potential therapeutic agents for human NAFLD." @default.
• W2085172008 created "2016-06-24" @default.
• W2085172008 creator A5002831772 @default.
• W2085172008 creator A5009110604 @default.
• W2085172008 creator A5045855833 @default.
• W2085172008 creator A5051226708 @default.
• W2085172008 creator A5052405555 @default.
• W2085172008 creator A5054724030 @default.
• W2085172008 creator A5078054175 @default.
• W2085172008 creator A5080364844 @default.
• W2085172008 creator A5084346418 @default.
• W2085172008 date "2008-11-01" @default.
• W2085172008 modified "2023-10-16" @default.
• W2085172008 title "Treatment of preestablished diet-induced fatty liver by oral fatty acid–bile acid conjugates in rodents" @default.
• W2085172008 cites W1523155649 @default.
• W2085172008 cites W1530129189 @default.
• W2085172008 cites W1967726960 @default.
• W2085172008 cites W1982680385 @default.
• W2085172008 cites W1988981256 @default.
• W2085172008 cites W1993822233 @default.
• W2085172008 cites W2001837599 @default.
• W2085172008 cites W2003623208 @default.
• W2085172008 cites W2005740242 @default.
• W2085172008 cites W2006611752 @default.
• W2085172008 cites W2017554448 @default.
• W2085172008 cites W2032129662 @default.
• W2085172008 cites W2040109162 @default.
• W2085172008 cites W2047257800 @default.
• W2085172008 cites W2053077555 @default.
• W2085172008 cites W2062663604 @default.
• W2085172008 cites W2063671857 @default.
• W2085172008 cites W2073953472 @default.
• W2085172008 cites W2085490751 @default.
• W2085172008 cites W2086324978 @default.
• W2085172008 cites W2090276592 @default.
• W2085172008 cites W2103156933 @default.
• W2085172008 cites W2105419408 @default.
• W2085172008 cites W2134955012 @default.
• W2085172008 cites W2139112405 @default.
• W2085172008 cites W2145326252 @default.
• W2085172008 cites W2151522593 @default.
• W2085172008 cites W2154075360 @default.
• W2085172008 cites W2160234571 @default.
• W2085172008 cites W2165103770 @default.
• W2085172008 doi "https://doi.org/10.1097/meg.0b013e3282fc9743" @default.
• W2085172008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18989145" @default.
• W2085172008 hasPublicationYear "2008" @default.
• W2085172008 type Work @default.
• W2085172008 sameAs 2085172008 @default.
• W2085172008 citedByCount "15" @default.
• W2085172008 countsByYear W20851720082012 @default.
• W2085172008 countsByYear W20851720082014 @default.
• W2085172008 countsByYear W20851720082015 @default.
• W2085172008 countsByYear W20851720082016 @default.
• W2085172008 countsByYear W20851720082017 @default.
• W2085172008 countsByYear W20851720082018 @default.
• W2085172008 countsByYear W20851720082019 @default.
• W2085172008 countsByYear W20851720082021 @default.
• W2085172008 countsByYear W20851720082023 @default.
• W2085172008 crossrefType "journal-article" @default.
• W2085172008 hasAuthorship W2085172008A5002831772 @default.
• W2085172008 hasAuthorship W2085172008A5009110604 @default.
• W2085172008 hasAuthorship W2085172008A5045855833 @default.
• W2085172008 hasAuthorship W2085172008A5051226708 @default.
• W2085172008 hasAuthorship W2085172008A5052405555 @default.
• W2085172008 hasAuthorship W2085172008A5054724030 @default.
• W2085172008 hasAuthorship W2085172008A5078054175 @default.
• W2085172008 hasAuthorship W2085172008A5080364844 @default.
• W2085172008 hasAuthorship W2085172008A5084346418 @default.
• W2085172008 hasConcept C126322002 @default.
• W2085172008 hasConcept C134018914 @default.
• W2085172008 hasConcept C2775900799 @default.
• W2085172008 hasConcept C2776954865 @default.
• W2085172008 hasConcept C2778772119 @default.
• W2085172008 hasConcept C2779134260 @default.
• W2085172008 hasConcept C2779399885 @default.
• W2085172008 hasConcept C543025807 @default.
• W2085172008 hasConcept C55493867 @default.
• W2085172008 hasConcept C71924100 @default.
• W2085172008 hasConcept C86803240 @default.
• W2085172008 hasConceptScore W2085172008C126322002 @default.
• W2085172008 hasConceptScore W2085172008C134018914 @default.
• W2085172008 hasConceptScore W2085172008C2775900799 @default.
• W2085172008 hasConceptScore W2085172008C2776954865 @default.
• W2085172008 hasConceptScore W2085172008C2778772119 @default.
• W2085172008 hasConceptScore W2085172008C2779134260 @default.
• W2085172008 hasConceptScore W2085172008C2779399885 @default.
• W2085172008 hasConceptScore W2085172008C543025807 @default.
• W2085172008 hasConceptScore W2085172008C55493867 @default.
• W2085172008 hasConceptScore W2085172008C71924100 @default.
• W2085172008 hasConceptScore W2085172008C86803240 @default.
• W2085172008 hasLocation W20851720081 @default.
• W2085172008 hasLocation W20851720082 @default.
• W2085172008 hasOpenAccess W2085172008 @default.
• W2085172008 hasPrimaryLocation W20851720081 @default.
• W2085172008 hasRelatedWork W1695174616 @default.
• W2085172008 hasRelatedWork W1973843004 @default.
• W2085172008 hasRelatedWork W2069194256 @default.

• next