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- W2085172055 abstract "Electrical stimulation of the cerebellar fastigial nucleus (FN) in rat (1 h) reduces, by 50%, the infarction produced by occlusion of the middle cerebral artery (MCAO). We investigated whether salvage was associated with elevations in regional cerebral blood flow (rCBF) and/or reductions of regional cerebral glucose utilization (rCGU) in the retrievable zone (RZ). rCGU and rCBF were measured autoradiographically 1 h after MCAO. MCAO reduced rCBF to < 15% in the irretrievable zone (IZ) and ∼ 50% in the RZ (P < 0.01 for each) while FN stimulation alone globally elevated rCBF by ∼ 60% (P < 0.01). rCGU was not changed. After MCAO, FN stimulation failed to increase the reduced rCBF but elevated rCGU globally (to ∼30%). Reductions of focal ischemic infarctions by stimulating FN cannot be attributed to changes in rCBF and or rCGU." @default.
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- W2085172055 date "1996-06-01" @default.
- W2085172055 modified "2023-09-23" @default.
- W2085172055 title "Electrical stimulation of cerebellar fastigial nucleus fails to rematch blood flow and metabolism in focal ischemic infarctions" @default.
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- W2085172055 doi "https://doi.org/10.1016/0304-3940(96)12682-3" @default.
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