Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085172814> ?p ?o ?g. }
- W2085172814 endingPage "153" @default.
- W2085172814 startingPage "140" @default.
- W2085172814 abstract "Mobile genetic elements termed transposons have been increasingly implicated in human disease. The small transposon mariner is widespread within non-vertebrate genomes and causes mutation by replication, excision, and insertion of itself without an RNA intermediate. We find that human DNA contains about 60 copies of this gene. Mariner transcripts are abundant in RNA prepared from sclerotic epileptic hippocampi. In contrast, typically no mariner-specific RNA is detected in non-sclerotic hippocampi from other epileptic patients or from autopsies. A complete but non-functional copy was obtained using rapid amplification of cDNA ends (RACE). This human mariner transcript is ∼45% homologous to a functional counterpart active in Drosophila, with a coding region of 1035 bases flanked by 32 base inverted terminal repeats. The differential expression of mariner transcripts within sclerotic hippocampi suggests the probable activity of an autonomous element which by mutating critical genes could establish an epileptogenic substrate in the hippocampus." @default.
- W2085172814 created "2016-06-24" @default.
- W2085172814 creator A5029709460 @default.
- W2085172814 creator A5034462876 @default.
- W2085172814 creator A5086671246 @default.
- W2085172814 date "1998-09-01" @default.
- W2085172814 modified "2023-09-27" @default.
- W2085172814 title "Transcripts of the transposon mariner are present in epileptic brain" @default.
- W2085172814 cites W1570545788 @default.
- W2085172814 cites W1578437221 @default.
- W2085172814 cites W1738249403 @default.
- W2085172814 cites W1779180564 @default.
- W2085172814 cites W1924707789 @default.
- W2085172814 cites W1968762182 @default.
- W2085172814 cites W1969989752 @default.
- W2085172814 cites W1971074898 @default.
- W2085172814 cites W1976031219 @default.
- W2085172814 cites W1978325633 @default.
- W2085172814 cites W1978368163 @default.
- W2085172814 cites W1979350018 @default.
- W2085172814 cites W1982266866 @default.
- W2085172814 cites W1985359136 @default.
- W2085172814 cites W2002602921 @default.
- W2085172814 cites W2006093394 @default.
- W2085172814 cites W2006758190 @default.
- W2085172814 cites W2017464780 @default.
- W2085172814 cites W2020902625 @default.
- W2085172814 cites W2027617009 @default.
- W2085172814 cites W2035169994 @default.
- W2085172814 cites W2038081057 @default.
- W2085172814 cites W2042871196 @default.
- W2085172814 cites W2049846352 @default.
- W2085172814 cites W2050367027 @default.
- W2085172814 cites W2053438733 @default.
- W2085172814 cites W2054385227 @default.
- W2085172814 cites W2055043387 @default.
- W2085172814 cites W2070807615 @default.
- W2085172814 cites W2074648209 @default.
- W2085172814 cites W2077214743 @default.
- W2085172814 cites W2079482933 @default.
- W2085172814 cites W2091798474 @default.
- W2085172814 cites W2092026879 @default.
- W2085172814 cites W2092724794 @default.
- W2085172814 cites W2094864604 @default.
- W2085172814 cites W2108388593 @default.
- W2085172814 cites W2123632586 @default.
- W2085172814 cites W2138085830 @default.
- W2085172814 cites W2144972963 @default.
- W2085172814 cites W2149998368 @default.
- W2085172814 cites W2160442132 @default.
- W2085172814 cites W2164268082 @default.
- W2085172814 cites W2169831229 @default.
- W2085172814 cites W2301000051 @default.
- W2085172814 cites W33791449 @default.
- W2085172814 cites W4247701447 @default.
- W2085172814 cites W4294216491 @default.
- W2085172814 doi "https://doi.org/10.1016/s0920-1211(98)00047-3" @default.
- W2085172814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9761316" @default.
- W2085172814 hasPublicationYear "1998" @default.
- W2085172814 type Work @default.
- W2085172814 sameAs 2085172814 @default.
- W2085172814 citedByCount "4" @default.
- W2085172814 crossrefType "journal-article" @default.
- W2085172814 hasAuthorship W2085172814A5029709460 @default.
- W2085172814 hasAuthorship W2085172814A5034462876 @default.
- W2085172814 hasAuthorship W2085172814A5086671246 @default.
- W2085172814 hasBestOaLocation W20851728141 @default.
- W2085172814 hasConcept C104317684 @default.
- W2085172814 hasConcept C141231307 @default.
- W2085172814 hasConcept C169760540 @default.
- W2085172814 hasConcept C187882448 @default.
- W2085172814 hasConcept C197077220 @default.
- W2085172814 hasConcept C2778186239 @default.
- W2085172814 hasConcept C4918238 @default.
- W2085172814 hasConcept C54355233 @default.
- W2085172814 hasConcept C67705224 @default.
- W2085172814 hasConcept C86803240 @default.
- W2085172814 hasConceptScore W2085172814C104317684 @default.
- W2085172814 hasConceptScore W2085172814C141231307 @default.
- W2085172814 hasConceptScore W2085172814C169760540 @default.
- W2085172814 hasConceptScore W2085172814C187882448 @default.
- W2085172814 hasConceptScore W2085172814C197077220 @default.
- W2085172814 hasConceptScore W2085172814C2778186239 @default.
- W2085172814 hasConceptScore W2085172814C4918238 @default.
- W2085172814 hasConceptScore W2085172814C54355233 @default.
- W2085172814 hasConceptScore W2085172814C67705224 @default.
- W2085172814 hasConceptScore W2085172814C86803240 @default.
- W2085172814 hasIssue "1-2" @default.
- W2085172814 hasLocation W20851728141 @default.
- W2085172814 hasLocation W20851728142 @default.
- W2085172814 hasOpenAccess W2085172814 @default.
- W2085172814 hasPrimaryLocation W20851728141 @default.
- W2085172814 hasRelatedWork W1573987240 @default.
- W2085172814 hasRelatedWork W1873126638 @default.
- W2085172814 hasRelatedWork W1927614236 @default.
- W2085172814 hasRelatedWork W2025648577 @default.
- W2085172814 hasRelatedWork W2034211922 @default.
- W2085172814 hasRelatedWork W2120762351 @default.