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• W2085178889 abstract "It has been proposed that an aggressive secondary cancer stem cell population arises from a primary cancer stem cell population through acquisition of additional genetic mutations and drives cancer progression. Overexpression of Polycomb protein EZH2, essential in stem cell self-renewal, has been linked to breast cancer progression. However, critical mechanism linking increased EZH2 expression to BTIC (breast tumor initiating cell) regulation and cancer progression remains unclear. Here, we identify a mechanism in which EZH2 expression-mediated downregulation of DNA damage repair leads to accumulation of recurrent RAF1 gene amplification in BTICs, which activates p-ERK-β-catenin signaling to promote BTIC expansion. We further reveal that AZD6244, a clinical trial drug that inhibits RAF1-ERK signaling, could prevent breast cancer progression by eliminating BTICs." @default.
• W2085178889 created "2016-06-24" @default.
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• W2085178889 date "2011-01-01" @default.
• W2085178889 modified "2023-10-16" @default.
• W2085178889 title "EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin Signaling" @default.
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• W2085178889 doi "https://doi.org/10.1016/j.ccr.2010.10.035" @default.
• W2085178889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3041516" @default.
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• W2085178889 hasPublicationYear "2011" @default.
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