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- W2085179915 abstract "In a transgenic rice line, a beta-glucuronidase reporter gene under the control of the rice tungro bacilliform virus promoter became gradually methylated, and gene activity was lost concomitantly. Methylation was observed only in the homozygous offspring and was initially restricted to the promoter region and accompanied by loss of expression in the vascular bundle tissue only. This expression pattern was similar to that of a promoter with a deletion of a vascular bundle expression element. The gene activity could be reestablished by treatment with 5-azacytidine. Methylation per se did not inhibit the binding to the promoter region of protein factors which also bound to the unmethylated sequence. Instead, promoter methylation enabled the alternative binding of a protein with specificity for sequence and methylation. In further generations of homozygous offspring the methylation spread into the transcribed region and gene activity was completely repressed also in nonvascular cells. The results indicate that different stages are involved in DNA methylation-correlated gene inactivation, and that at least one of them may involve the attraction of a sequence and methylation-specific DNA-binding protein." @default.
- W2085179915 created "2016-06-24" @default.
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- W2085179915 creator A5079592113 @default.
- W2085179915 creator A5088061646 @default.
- W2085179915 date "2002-07-19" @default.
- W2085179915 modified "2023-10-13" @default.
- W2085179915 title "Tissue-specific silencing of a transgene in rice" @default.
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- W2085179915 doi "https://doi.org/10.1073/pnas.152330299" @default.
- W2085179915 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/125067" @default.
- W2085179915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12134059" @default.
- W2085179915 hasPublicationYear "2002" @default.
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