Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085181566> ?p ?o ?g. }
- W2085181566 endingPage "1173" @default.
- W2085181566 startingPage "1160" @default.
- W2085181566 abstract "Protein kinase A (PKA) hyperactivation causes hereditary endocrine neoplasias; however, its role in sporadic epithelial cancers is unknown. Here, we show that heightened PKA activity in the mammary epithelium generates tumors. Mammary-restricted biallelic ablation of Prkar1a, which encodes for the critical type-I PKA regulatory subunit, induced spontaneous breast tumors characterized by enhanced type-II PKA activity. Downstream of this, Src phosphorylation occurs at residues serine-17 and tyrosine-416 and mammary cell transformation is driven through a mechanism involving Src signaling. The phenotypic consequences of these alterations consisted of increased cell proliferation and, accordingly, expansion of both luminal and basal epithelial cell populations. In human breast cancer, low PRKAR1A/high SRC expression defines basal-like and HER2 breast tumors associated with poor clinical outcome. Together, the results of this study define a novel molecular mechanism altered in breast carcinogenesis and highlight the potential strategy of inhibiting SRC signaling in treating this cancer subtype in humans." @default.
- W2085181566 created "2016-06-24" @default.
- W2085181566 creator A5007683114 @default.
- W2085181566 creator A5037724688 @default.
- W2085181566 creator A5041068525 @default.
- W2085181566 creator A5043055023 @default.
- W2085181566 creator A5044186566 @default.
- W2085181566 creator A5044574662 @default.
- W2085181566 creator A5053036485 @default.
- W2085181566 creator A5068005383 @default.
- W2085181566 creator A5071359533 @default.
- W2085181566 creator A5078650117 @default.
- W2085181566 date "2014-03-24" @default.
- W2085181566 modified "2023-10-18" @default.
- W2085181566 title "PKA signaling drives mammary tumorigenesis through Src" @default.
- W2085181566 cites W1963685103 @default.
- W2085181566 cites W1969180149 @default.
- W2085181566 cites W1970075023 @default.
- W2085181566 cites W1980073590 @default.
- W2085181566 cites W1981801066 @default.
- W2085181566 cites W1982093899 @default.
- W2085181566 cites W1984433201 @default.
- W2085181566 cites W1988344527 @default.
- W2085181566 cites W1992873952 @default.
- W2085181566 cites W2005895632 @default.
- W2085181566 cites W2011901471 @default.
- W2085181566 cites W2022440206 @default.
- W2085181566 cites W2028650359 @default.
- W2085181566 cites W2032087197 @default.
- W2085181566 cites W2038653804 @default.
- W2085181566 cites W2041445540 @default.
- W2085181566 cites W2050297059 @default.
- W2085181566 cites W2055737181 @default.
- W2085181566 cites W2058451329 @default.
- W2085181566 cites W2071901592 @default.
- W2085181566 cites W2077469282 @default.
- W2085181566 cites W2080982938 @default.
- W2085181566 cites W2082972065 @default.
- W2085181566 cites W2089258206 @default.
- W2085181566 cites W2096283457 @default.
- W2085181566 cites W2100091556 @default.
- W2085181566 cites W2106195176 @default.
- W2085181566 cites W2109591845 @default.
- W2085181566 cites W2115118052 @default.
- W2085181566 cites W2117535295 @default.
- W2085181566 cites W2120261416 @default.
- W2085181566 cites W2121535393 @default.
- W2085181566 cites W2124127909 @default.
- W2085181566 cites W2125025556 @default.
- W2085181566 cites W2128744203 @default.
- W2085181566 cites W2130410032 @default.
- W2085181566 cites W2132619562 @default.
- W2085181566 cites W2143905730 @default.
- W2085181566 cites W2144193044 @default.
- W2085181566 cites W2144847348 @default.
- W2085181566 cites W2145533373 @default.
- W2085181566 cites W2149367281 @default.
- W2085181566 cites W2152098033 @default.
- W2085181566 cites W2156527837 @default.
- W2085181566 cites W2160450758 @default.
- W2085181566 cites W2171087521 @default.
- W2085181566 cites W2334487286 @default.
- W2085181566 cites W4294107304 @default.
- W2085181566 doi "https://doi.org/10.1038/onc.2014.41" @default.
- W2085181566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24662820" @default.
- W2085181566 hasPublicationYear "2014" @default.
- W2085181566 type Work @default.
- W2085181566 sameAs 2085181566 @default.
- W2085181566 citedByCount "71" @default.
- W2085181566 countsByYear W20851815662014 @default.
- W2085181566 countsByYear W20851815662015 @default.
- W2085181566 countsByYear W20851815662016 @default.
- W2085181566 countsByYear W20851815662017 @default.
- W2085181566 countsByYear W20851815662018 @default.
- W2085181566 countsByYear W20851815662019 @default.
- W2085181566 countsByYear W20851815662020 @default.
- W2085181566 countsByYear W20851815662021 @default.
- W2085181566 countsByYear W20851815662022 @default.
- W2085181566 countsByYear W20851815662023 @default.
- W2085181566 crossrefType "journal-article" @default.
- W2085181566 hasAuthorship W2085181566A5007683114 @default.
- W2085181566 hasAuthorship W2085181566A5037724688 @default.
- W2085181566 hasAuthorship W2085181566A5041068525 @default.
- W2085181566 hasAuthorship W2085181566A5043055023 @default.
- W2085181566 hasAuthorship W2085181566A5044186566 @default.
- W2085181566 hasAuthorship W2085181566A5044574662 @default.
- W2085181566 hasAuthorship W2085181566A5053036485 @default.
- W2085181566 hasAuthorship W2085181566A5068005383 @default.
- W2085181566 hasAuthorship W2085181566A5071359533 @default.
- W2085181566 hasAuthorship W2085181566A5078650117 @default.
- W2085181566 hasBestOaLocation W20851815661 @default.
- W2085181566 hasConcept C108636557 @default.
- W2085181566 hasConcept C11960822 @default.
- W2085181566 hasConcept C121608353 @default.
- W2085181566 hasConcept C126322002 @default.
- W2085181566 hasConcept C2778001805 @default.
- W2085181566 hasConcept C42362537 @default.
- W2085181566 hasConcept C502942594 @default.