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• W2085181862 startingPage "441" @default.
• W2085181862 abstract "The fusogenic lipid diacylglycerol is essential for remodeling gamete and zygote nuclear envelopes (NE) during early embryogenesis. It is unclear whether upstream signaling molecules are likewise conserved. Here we demonstrate PLCγ and its activator SFK1, which co-operate during male pronuclear envelope formation, also promote the subsequent male and female pronuclear fusion. PLCγ and SFK1 interact directly at the fusion site leading to PLCγ activation. This is accompanied by a spatially restricted reduction of PtdIns(4,5)P2. Consequently, pronuclear fusion is blocked by PLCγ or SFK1 inhibition. These findings identify new regulators of events in the early embryo and suggest a conserved “toolkit” of fusion machinery drives successive NE fusion events during embryogenesis." @default.
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• W2085181862 date "2014-08-11" @default.
• W2085181862 modified "2023-09-25" @default.
• W2085181862 title "Conservation of proteo-lipid nuclear membrane fusion machinery during early embryogenesis" @default.
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• W2085181862 doi "https://doi.org/10.4161/nucl.34422" @default.
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